Safety and immunogenicity of Haemophilus influenzae type B polysaccharide-diphtheria toxoid conjugate vaccine in adults.
Safety and immunogenicity of Haemophilus influenzae type B polysaccharide-diphtheria toxoid conjugate vaccine in adults.
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B 型流感嗜血杆菌多糖-白喉类毒素结合疫苗在成人中的安全性和免疫原性。
DOI：
10.1093/infdis/150.3.402
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Gordon,LK
中科院分区：
文献类型：
--
作者：
Lepow,ML;Samuelson,JS;Gordon,LK
61名成人接种了b型流感嗜血杆菌囊型多聚核糖磷酸(PRP)疫苗或ORH。乙型流感多糖-白喉类毒素结合物(PRP-D)疫苗分两次接种，间隔一个月。两种疫苗耐受性良好，没有发烧或全身反应。没有明显的局部反应。两组中都有大约一半的受试者报告有轻微的局部压痛。在免疫前、第一次接种后一个月和第二次接种后7-10天评估的血液学参数，包括网织红细胞和血小板计数，没有观察到疫苗的影响。第一次接种1个月后，单剂PRP-D诱导的PRP抗体水平是单独接种PRP的3倍。
Sixty-one adults received eitherHaemophilus influenzaetype b capsular polyribosephosphate (PRP) vaccine orH. influenzaetype b polysaccharide-diphtheria toxoid conjugate (PRP-D) vaccine in two doses, one month apart. Both vaccines were well tolerated with no fever or systemic reactions. There were no significant local reactions. Mild local tenderness was reported by about half of the subjects in both groups. There was no observed effect of the vaccines on hematologic parameters, including reticulocyte and platelet counts, evaluated before immunization, one month after the first dose, and seven to 10 days after the second dose. A single dose of PRP-D induced levels of IgG antibody to PRP three times that observed with PRP alone one month after the first inoculation.