Personal history of proliferative breast disease with atypia and risk of multifocal breast cancer.
Personal history of proliferative breast disease with atypia and risk of multifocal breast cancer.
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作者：
Nutter EL;Weiss JE;Marotti JD;Barth RJ Jr;Eliassen MS;Goodrich ME;Petersen CL;Onega T
A history of proliferative breast disease with atypia (PBDA) may be indicative of an increased risk not just of breast cancer, but of a more aggressive form of breast cancer. Multifocal breast cancer (MFBC), defined as two or more tumors in the same breast upon cancer diagnosis, is associated with poorer prognosis than unifocal (single tumor) breast cancer. PBDA, including atypical ductal hyperplasia and atypical lobular hyperplasia, is a known risk factor for breast cancer. Using New Hampshire Mammography Network data collected on 3,567 women diagnosed with incident breast cancer from 2004–2014, we assessed the risk of MFBC associated with a previous diagnosis of PBDA. Women with a history of PBDA were found to be twice as likely to be subsequently diagnosed with MFBC than women with no history of benign breast disease (BBD) (OR = 2.23; CI: 1.08 – 4.61). Ductal carcinoma in situ on initial biopsy was associated with a two-fold increased risk of MFBC when compared to invasive cancer (OR = 2.13; CI: 1.58 – 2.88). BBD and proliferative BBD without atypia were not associated with MFBC. Women with a history of previous PBDA may be at increased risk for MFBC. Women with a history of PBDA may benefit from additional pre-surgical clinical workup.
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影响因子：
7.3
作者：
Bombonati, Alessandro;Sgroi, Dennis C.
通讯作者：
Sgroi, Dennis C.
DOI：
10.1002/path.4540
发表时间：
2015-08
期刊：
The Journal of pathology
影响因子：
--
作者：
Desmedt C;Fumagalli D;Pietri E;Zoppoli G;Brown D;Nik-Zainal S;Gundem G;Rothé F;Majjaj S;Garuti A;Carminati E;Loi S;Van Brussel T;Boeckx B;Maetens M;Mudie L;Vincent D;Kheddoumi N;Serra L;Massa I;Ballestrero A;Amadori D;Salgado R;de Wind A;Lambrechts D;Piccart M;Larsimont D;Campbell PJ;Sotiriou C
通讯作者：
Sotiriou C
影响因子：
19.7
作者：
Poplack, SP;Tosteson, AN;Carney, PA
通讯作者：
Carney, PA
影响因子：
19.7
作者：
Berg, WA;Gilbreath, PL
通讯作者：
Gilbreath, PL
影响因子：
5
作者：
Carney, PA;Poplack, SP;Littenberg, B
通讯作者：
Littenberg, B