Asymmetric Carbolithiation of Conjugated Enynes: A Flow Microreactor Enables the Use of Configurationally Unstable Intermediates before They Epimerize
Asymmetric Carbolithiation of Conjugated Enynes: A Flow Microreactor Enables the Use of Configurationally Unstable Intermediates before They Epimerize
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共轭烯炔的不对称碳锂化：流动微反应器能够在差向异构化之前使用构型不稳定的中间体
DOI：
10.1002/chin.201131063
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发表时间：
2011
影响因子：
15
通讯作者：
J.
中科院分区：
文献类型：
--
作者：
Tomida;Y.; Nagaki;A.; Yoshida;J.
我们发现流动微反应器系统能够生成构型不稳定的手性有机锂中间体，并允许其在差向异构化之前用于与亲电子试剂的反应。基于该方法，完成了共轭烯炔的对映选择性碳锂化，然后与亲电子试剂反应，得到了对映体富集的手性丙二烯。
We found that a flow microreactor system enables the generation of a configurationally unstable chiral organolithium intermediate and allows for its use in a reaction with an electrophile before it epimerizes. Based on this method, the enantioselective carbolithiation of conjugated enynes followed by the reaction with electrophiles was accomplished to obtain enantioenriched chiral allenes.