The role of transforming growth factor-β signalling in the patterning of the proximal processes of the murine dentary
The role of transforming growth factor-β signalling in the patterning of the proximal processes of the murine dentary
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DOI：
10.1002/dvdy.21567
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发表时间：
2008-06-01
影响因子：
2.5
通讯作者：
Tucker, Abigail S.
中科院分区：
文献类型：
--
作者：
Anthwal, Neal;Chai, Yang;Tucker, Abigail S.
新型哺乳动物颌关节的进化导致了近齿骨的复杂性增加，反映了它现在作为下颌骨的主要骨骼的多重作用。通过tgf - β II型受体的信号传导在近端牙突，特别是角突和次级软骨的发育和定型中是重要的。我们发现tgf - β 2的表达与形成角过程有关，结缔组织标志物sclaxis与tgf - β 2共表达。sccleraxis的表达在Tgthr2条件敲除的角度过程中丢失，tgf - β信号可以诱导外植体培养中sccleraxis的表达。诱导次生软骨的外植体培养可以通过抑制tgf - β信号传导。这项研究表明，这些突及其次生软骨的正常发育依赖于tgf - β信号和机械力的协同作用。
The evolution of the novel mammalian jaw articulation has resulted in an increased complexity of the dentary bone, reflecting the multiple roles it now fulfils as the primary bone of the mandible. Signalling through the Tgf-beta type II receptor is important in the development and patterning of the proximal dentary processes, especially the angular process, and secondary cartilages. We show that expression of Tgf-beta 2 is associated with the developing angular process, and that the connective tissue marker Scleraxis is co-expressed with Tgf-beta 2. Scleraxis expression is lost around the angular process of Tgthr2 conditional knockouts and Tgf-beta signalling can induce Scleraxis expression in explant culture. Induction of secondary cartilages in explant culture can be prevented by inhibition of Tgf-beta signalling. This study suggests that the proper development of the processes and their secondary cartilages relies on both Tgf-beta signalling and mechanical forces working in concert.