Chiral-at-Metal Rh(III) Complex Catalyzed Cascade Reduction-Michael Addition Reaction
Chiral-at-Metal Rh(III) Complex Catalyzed Cascade Reduction-Michael Addition Reaction
复制标题
金属手性 Rh(III) 配合物催化级联还原-迈克尔加成反应
DOI：
10.1021/acs.joc.9b02243
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发表时间：
2019
影响因子：
3.6
通讯作者：
Du Yu
中科院分区：
文献类型：
--
作者：
Wan Qian;Li Shiwu;Kang Qiang;Yuan Yaofeng;Du Yu
研究了手性金属铑（III）配合物催化的对映选择性三组分级联还原-迈克尔加成反应。以汉氏酯为氢化物源，制备了许多产率高、对映选择性好的丙二腈衍生物。在实验的基础上，提出了一个解释立体选择性产生原因和影响因素的模型。
An enantioselective three-component cascade reduction-Michael addition reaction catalyzed by chiral-at-metal Rh(III) complexes has been developed. With a Hantzsch ester as the hydride source, a number of malononitrile derivatives were prepared in good yields and excellent enantioselectivities. A model that accounts for the origin and influence factors of the stereoselectivity has been proposed based on experiments.