The intestinal microbiota and anorexia nervosa: cause or consequence of nutrient deprivation.
The intestinal microbiota and anorexia nervosa: cause or consequence of nutrient deprivation.
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DOI：
10.1016/j.coemr.2021.06.003
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发表时间：
2021-08
影响因子：
--
通讯作者：
Carroll IM
中科院分区：
文献类型：
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作者：
Reed KK;Abbaspour A;Bulik CM;Carroll IM
肠道微生物群是定植于动物胃肠道的多样化微生物群落。肠道微生物群的异常变化与多种疾病有关，包括炎症性肠病和肥胖；然而，新的证据表明肠道微生物群通过肠-脑轴在焦虑和抑郁中发挥作用。由于这种微生物群落与体重失调和宿主行为有关，因此肠道微生物群可能在神经性厌食症 (AN) 中发挥作用也就不足为奇了。在这篇综述中，我们研究了最近将肠道微生物群与营养、精神病理学以及最终的AN联系起来的研究。我们还回顾了基于肠道微生物群的潜在 AN 疗法。
The intestinal microbiota is a diverse microbial community that colonizes the gastrointestinal tract of animals. Abnormal changes in intestinal microbiota has been associated with multiple diseases including inflammatory bowel diseases and obesity; however, emerging evidence suggests a role for the gut microbiota in anxiety and depression via the gut-brain axis. As this microbial community is associated with weight dysregulation and host behavior it is not surprising that the intestinal microbiota may have a role to play in anorexia nervosa (AN). In this review we examine recent studies linking the gut microbiota with nutrition, psychopathology, and ultimately AN. We also review potential gut microbiota-based therapies for AN.