The impact of symptoms, coping capacity, and social support on quality of life experience over time in patients with lung cancer
The impact of symptoms, coping capacity, and social support on quality of life experience over time in patients with lung cancer
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DOI：
10.1016/j.jpainsymman.2006.12.005
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发表时间：
2007-10-01
影响因子：
4.7
通讯作者：
Danielson, Ella
中科院分区：
文献类型：
--
作者：
Henoch, Ingela;Bergman, Bengt;Danielson, Ella
本研究的目的是调查肺癌患者在姑息治疗环境下的生活质量，并确定生活质量如何受到症状、应对能力和社会支持的影响。纳入了105例连续的不治之症肺癌患者。基线时使用了一套全面的调查问卷，包括生命末期生活质量评估、癌症呼吸困难量表、呼吸困难视觉模拟量表、医院焦虑和抑郁量表、连贯性问卷和社会支持调查，其中前四项在3个月、6个月、9个月和12个月时也使用。随着时间的推移，呼吸困难、抑郁和总体生活质量恶化。表现状态、焦虑、抑郁、呼吸困难成分、疼痛和应对能力的意义成分与总体生活质量相关，或除一项随访测量外，其他所有测量均与总体生活质量相关。在以总体生活质量为因变量的多变量分析中，抑郁在五项评估中有四项是重要的预测因子，而应对能力、焦虑、表现状态、疼痛和社会支持在一项或两项评估中进入模型。情绪困扰和应对能力影响生活质量，可能是姑息治疗干预的目标。
The aims of the study were to investigate lung cancer patients' quality of life (QoL) over time in a palliative setting and to determine how QoL is influenced by symptoms, coping capacity, and social support. One hundred and five consecutive patients with incurable lung cancer were included. A comprehensive set of questionnaires was used at baseline, including the Assessment of Quality of Life at the End of Life, Cancer Dyspnea Scale, Visual Analog Scale of Dyspnea, Hospital Anxiety and Depression scale, Sense of Coherence Questionnaire, and Social Support Survey, of which the first four were used also at three, six, nine, and 12 months. Dyspnea, depression, and global QoL deteriorated over time. Performance status, anxiety, depression, components of dyspnea, pain, and the meaningfulness component of coping capacity correlated with global QoL at all, or all but one follow-up measurements. In a multivariate analysis with global QoL as the dependent variable, depression was a significant predictor at four out of five assessments, whereas coping capacity, anxiety, performance status, pain, and social support entered the model at one or two assessments. Emotional distress and coping capacity influence QoL and might be targets for intervention in Palliative care.