Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress
Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress
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DOI：
10.1080/10253890410001728379
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发表时间：
2004-06-01
影响因子：
2.3
通讯作者：
Hellhammer, D
中科院分区：
文献类型：
--
作者：
Hellhammer, J;Fries, E;Hellhammer, D
从牛脑中提取的磷脂酰丝氨酸，此前已被证明可以抑制ACTH和皮质醇对身体压力的反应。进一步的研究调查了补充大豆卵磷脂磷脂酰丝氨酸在面对急性应激源时对情绪和心率的影响。在这项研究中，我们研究了补充大豆卵磷脂磷脂酸和磷脂酰丝氨酸复合体(PAS)对垂体肾上腺反应性(ACTH和皮质醇)以及对心理和情绪应激源的心理反应(斯皮尔伯格状态焦虑问卷压力子量表)的影响。在接受Trier社会压力测试(TSST)之前，四组20名受试者接受了为期三周的治疗，每天服用400 mg PAS、600 mg PAS、800 mg PAS或安慰剂。400 mg PAS治疗后，血清ACTH和皮质醇以及唾液皮质醇对TSST的反应均明显减弱，但不影响心率。较大剂量的PAS则看不到这种效果。在心理反应方面，400 mg PAS似乎对TSST的情绪反应有特定的积极作用。虽然安慰剂组在测试后表现出预期的痛苦增加，但接受400毫克PAS治疗的组表现出减少的痛苦。这些数据为PAS对垂体-肾上腺轴的选择性应激抑制作用提供了初步证据，表明PAS在治疗应激相关疾病方面的潜力。
Phosphatidylserine, derived from cow brains, has been shown previously to dampen the ACTH and cortisol response to physical stress. Further research investigated the influence of soy lecithin phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. In this study, we investigated the effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) supplementation on pituitary adrenal reactivity (ACTH, cortisol) and on the psychological response (Spielberger State Anxiety Inventory stress subscale) to a mental and emotional stressor. Four groups of 20 subjects were treated for three weeks with daily dosages of either 400 mg PAS, 600 mg PAS, 800 mg PAS, or placebo before exposure to the Trier Social Stress Test (TSST). Treatment with 400 mg PAS resulted in a pronounced blunting of both serum ACTH and cortisol, and salivary cortisol responses to the TSST, but did not affect heart rate. The effect was not seen with larger doses of PAS. With regard to the psychological response, 400 mg PAS seemed to exert a specific positive effect oil emotional responses to the TSST. While the placebo group showed the expected increase in distress after the test, the group treated with 400 mg PAS showed decreased distress. These data provide initial evidence for a selective stress dampening effect of PAS on the pituitary-adrenal axis, suggesting the potential of PAS in the treatment of stress related disorders.