Topographic movie of intracranial ictal high-frequency oscillations with seizure semiology: Epileptic network in Jacksonian seizures
Topographic movie of intracranial ictal high-frequency oscillations with seizure semiology: Epileptic network in Jacksonian seizures
复制标题
DOI：
10.1111/j.1528-1167.2010.02776.x
复制
发表时间：
2011-01-01
期刊：
影响因子：
5.6
通讯作者：
Otsubo, Hiroshi
中科院分区：
文献类型：
--
作者：
Akiyama, Tomoyuki;Chan, Derrick W.;Otsubo, Hiroshi
P>目的：我们开发了一种技术，可以生成在硬膜下脑电图 (EEG) 上记录的发作期高频振荡 (HFO) > 40 Hz 的动态变化图像，这些图像与发作期脑电图和发作症状学视频时间锁定。我们将该技术应用于杰克逊癫痫发作，以证明发作期 HFO 沿着初级感觉运动皮层的小人传播，从而可视化潜在的癫痫网络。方法：我们分析了两名接受癫痫手术的顽固性杰克逊癫痫发作患者的颅内发作期脑电图。我们计算了与发作间期相比在40-80、80-200和200-300 Hz频段内的振幅增加程度，并将其转换成投影到大脑表面图像上的地形电影。我们将这些数据与患者的发作期脑电图和视频相结合，展示发作期症状学。主要发现：发作期 HFO 始于感觉皮层，并与感觉先兆同时出现。然后，在局部运动症状出现的同时，它们传播到运动皮层。随着癫痫发作的进展，发作期的 HFO 在罗兰区扩散或回响。然而，即使癫痫发作继发为全身性，发作期 HFO 也仅限于罗兰区。在这两种情况下，与癫痫发作过程相比，癫痫发作期间较高频段的振幅有所增加。意义：这部组合影片显示了与杰克逊癫痫发作的发作症状学相对应的发作期 HFO 传播，并揭示了参与癫痫发作和进展的癫痫网络。该方法可以促进对与临床癫痫发作产生和传播相关的神经网络活动的理解。
P>Purpose:We developed a technique to produce images of dynamic changes in ictal high-frequency oscillations (HFOs) > 40 Hz recorded on subdural electroencephalography (EEG) that are time-locked to the ictal EEG and ictal semiology video. We applied this technique to Jacksonian seizures to demonstrate ictal HFO propagation along the homunculus in the primary sensory-motor cortex to visualize the underlying epileptic network.Methods:We analyzed intracranial ictal EEGs from two patients with intractable Jacksonian seizures who underwent epilepsy surgery. We calculated the degrees of increase in amplitude within 40-80, 80-200, and 200-300 Hz frequency bands compared to the interictal period and converted them into topographic movies projected onto the brain surface picture. We combined these data with the ictal EEGs and video of the patient demonstrating ictal semiology.Key Findings:The ictal HFOs began in the sensory cortex and appeared concomitantly with the sensory aura. They then propagated to the motor cortex at the same time that focal motor symptoms evolved. As the seizure progressed, the ictal HFOs spread or reverberated in the rolandic region. However, even when the seizure became secondarily generalized, the ictal HFOs were confined to the rolandic region. In both cases, there was increased amplitude of higher frequency bands during seizure initiation compared to seizure progression.Significance:This combined movie showed the ictal HFO propagation corresponding to the ictal semiology in Jacksonian seizures and revealed the epileptic network involved in seizure initiation and progression. This method may advance understanding of neural network activities relating to clinical seizure generation and propagation.