A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control
复制标题
DOI：
10.1126/science.287.5460.2026
复制
发表时间：
2000-03-17
期刊：
影响因子：
56.9
通讯作者：
York, JD
中科院分区：
文献类型：
--
作者：
Odom, AR;Stahlberg, A;York, JD
磷脂酶C和两个肌醇多聚磷酸(IP)激酶构成一个信号通路，通过产生六磷酸肌醇(IP6)来调节核信使RNA的输出。酿酒酵母中该途径的三磷酸肌醇激酶，命名为Ipk2，与转录复合体ArgR-Mcm1的调节因子Arg82相同。通过ArgR-Mcm1进行基因调控需要合成肌醇1，4，5，6-四氢磷酸，而不是IP6。因此，磷脂酶C途径产生多个IP信使，调节不同的核过程。这些结果揭示了IP信号激活可能控制基因表达的直接机制。
Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6, was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.