Supramolecular Control of Selectivity in Hydroformylation of Vinyl Arenes: Easy Access to Valuable β-Aldehyde Intermediates
Supramolecular Control of Selectivity in Hydroformylation of Vinyl Arenes: Easy Access to Valuable β-Aldehyde Intermediates
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DOI：
10.1002/anie.201209582
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发表时间：
2013-01-01
影响因子：
16.6
通讯作者：
Reek, Joost N. H.
中科院分区：
文献类型：
--
作者：
Dydio, Pawel;Reek, Joost N. H.
逆流而上！报道了一种合理设计的区域选择性加氢催化剂[Rh/L]，其中非共价配体-底物相互作用允许从典型的α-醛到另外不利的产物β-醛的选择性的前所未有的逆转。该催化体系为精细化工行业的重要中间体开辟了新的可持续合成途径。
Go against the flow! A rationally designed regioselective hydroformylation catalyst,[Rh/L], in which noncovalent ligand–substrate interactions allow the unprecedented reversal of selectivity from the typical α‐aldehyde to the otherwise unfavored product β‐aldehyde, is reported. This catalytic system opens up novel and sustainable synthetic pathways to important intermediates for the fine‐chemicals industry.