Linking endothelial dysfunction with endothelial cell activation
Linking endothelial dysfunction with endothelial cell activation
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DOI：
10.1172/jci66843
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发表时间：
2013-02-01
影响因子：
15.9
通讯作者：
Liao, James K.
中科院分区：
文献类型：
--
作者：
Liao, James K.
排列在血管内部的薄层细胞，称为内皮细胞，在血管生物学中起着复杂的作用。内皮介导血管张力、止血、中性粒细胞募集、激素运输和液体过滤。内皮功能障碍，定义为缺乏NO，与多种疾病状态有关，包括动脉粥样硬化、糖尿病、冠状动脉疾病、高血压和高胆固醇血症。事实上，内皮功能的恢复是他汀类药物治疗最早认识到的益处之一。1995年，James Liao及其同事在JCI上发表了一项研究，证明NO是一种血管保护因子，可限制内皮细胞活化并防止白细胞粘附到血管壁。
The thin layer of cells that lines the interior of blood vessels, known as the endothelium, plays a complex role in vascular biology. The endothelium mediates blood vessel tone, hemostasis, neutrophil recruitment, hormone trafficking, and fluid filtration. Endothelial dysfunction, as defined by a lack of NO, has been linked to a variety of disease states, including atherosclerosis, diabetes mellitus, coronary artery disease, hypertension, and hypercholesterolemia. Indeed, restoration of endothelial function is one of the earliest recognizable benefits of statin therapy. In 1995, James Liao and colleagues published a study in the JCI demonstrating that NO is a vascular protective factor that limits endothelial activation and prevents leukocyte adhesion to the vessel wall.