Necrotising enterocolitis hospitalisations among neonates in the United States
Necrotising enterocolitis hospitalisations among neonates in the United States
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DOI：
10.1111/j.1365-3016.2006.00756.x
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发表时间：
2006-11-01
影响因子：
2.8
通讯作者：
Schonberger, Lawrence B.
中科院分区：
文献类型：
--
作者：
Holman, Robert C.;Stoll, Barbara J.;Schonberger, Lawrence B.
本研究的目的是评估美国住院新生儿（1月龄以下婴儿）中坏死性小肠结肠炎（NEC）的发生率并描述其流行病学。从2000年儿童住院患者数据库中选择NEC诊断和院内死亡或常规出院的新生儿出院记录进行分析。2000年期间，美国新生儿中估计发生了4463例（SE = 219）与NEC相关的住院，导致住院率为109.9 [95% CI 97.2，122.6]/100 000例活产。NEC住院率在非西班牙裔黑人新生儿中最高。平均住院时间为49天，住院病死率为15.2%（SE = 1.0%）。在住院期间接受手术的新生儿比那些没有接受手术干预的新生儿更有可能住院更长时间并死亡。与因其他诊断住院的低出生体重（LBW）新生儿相比，患有NEC的低出生体重（LBW）新生儿更有可能是极低出生体重（VLBW）、非西班牙裔黑人和男性。此外，与其他诊断住院的LBW新生儿相比，NEC的LBW新生儿住院费用更高，住院时间更长，更有可能在住院期间死亡。这项研究提供了美国新生儿NEC住院率的第一个全国性估计。2000年期间，每1 000例活产中有1例NEC住院，约7例NEC住院中有1例死亡。NEC占相当大的发病率，因此，预防战略和有效治疗的发展仍然是一个重要的问题。
The objective of this study was to estimate the rate and describe the epidemiology of necrotising enterocolitis (NEC) among neonates (infants < 1 month of age) hospitalised in the United States. Hospital discharge records for neonates with an NEC diagnosis and an in-hospital death or routine discharge were selected for analysis from the 2000 Kids' Inpatient Database. An estimated 4463 (SE = 219) hospitalisations associated with NEC occurred among neonates in the United States during the year 2000, resulting in a hospitalisation rate of 109.9 [95% CI 97.2, 122.6] per 100 000 livebirths. The rate of NEC hospitalisations was highest among non-Hispanic Black neonates. The median hospital length of stay was 49 days.The in-hospital fatality rate was 15.2% (SE = 1.0%). Neonates who underwent a surgical procedure during hospitalisation were more likely to have a longer length of stay and to die than were those who did not have surgical intervention. Low-birthweight (LBW) neonates with NEC were more likely than LBW neonates hospitalised with other diagnoses to be very LBW (VLBW), non-Hispanic Black and male. In addition, compared with LBW neonates hospitalised with other diagnoses, LBW neonates with NEC had higher hospital charges and longer lengths of stay, and were more likely to die during hospitalisation. This study provides the first national estimate of the rate of hospitalisation for NEC among neonates in the United States. During 2000, there was one NEC hospitalisation per 1000 livebirths, with approximately 1 in 7 NEC hospitalisations ending in death. NEC accounts for substantial morbidity; thus, the development of prevention strategies and effective therapies continues to be an important issue.