Nasal hyperreactivity in allergic and non-allergic rhinitis: a potential risk factor for non-specific building-related illness
Nasal hyperreactivity in allergic and non-allergic rhinitis: a potential risk factor for non-specific building-related illness
复制标题
DOI：
10.1111/j.1600-0668.2007.00482.x
复制
发表时间：
2007-08-01
期刊：
影响因子：
5.8
通讯作者：
Murphy, M. A.
中科院分区：
文献类型：
--
作者：
Shusterman, D.;Murphy, M. A.
自我报告的非过敏性鼻炎的非过敏性鼻症状触发因素与非特异性建筑物相关疾病中常见的环境暴露重叠。这些包括极端的温度和湿度，清洁产品，香水和烟草烟雾。一些过敏性鼻炎患者也报告非过敏性触发因素。我们希望通过确定过敏性鼻炎患者中自我报告的非过敏性鼻部症状触发因素来探讨过敏性鼻炎和非过敏性鼻炎之间的表型重叠。对60例无工作相关呼吸道暴露或症状的受试者（年龄19-68岁，按年龄、性别和（皮肤试验证实的）过敏性鼻炎状态分层）进行了关于自我报告的非过敏性鼻部症状触发因素（总评分0-8）的质询。在这个样本中，自我报告的非过敏性触发物的数量是双峰的，峰值在1和5。42%的季节性变应性鼻炎患者报告了三种以上的非变应性诱因，而非变应性非鼻炎患者中只有3%报告了三种以上的非变应性诱因（P < 0.01）。35岁以上的受试者更有可能报告一个或多个非过敏性触发因素，特别是烟草烟雾（P < 0.05）。过敏性鼻炎报告更多的非过敏性症状触发比非过敏性，非鼻炎。根据自我报告的对非特异性物理和化学触发因素的反应性，非过敏性鼻病患者和过敏性鼻病患者的一部分可能构成非特异性建筑相关疾病的易感人群。
Self-reported non-allergic nasal symptom triggers in non-allergic ('vasomotor') rhinitis overlap with commonly identified environmental exposures in non-specific building-related illness. These include extremes of temperature and humidity, cleaning products, fragrances, and tobacco smoke. Some individuals with allergic rhinitis also report non-allergic triggers. We wished to explore the phenotypic overlap between allergic and non-allergic rhinitis by ascertaining self-reported non-allergic nasal symptom triggers among allergic rhinitics. Sixty subjects without work-related respiratory exposures or symptoms, aged 19-68 years, stratified by age, gender and (skin test-proven) allergic rhinitis status, were queried with regard to self-reported non-allergic nasal symptom triggers (aggregate score 0-8). In this sample, the number of self-reported non-allergic triggers was bimodal, with peaks at 1 and 5. Forty-two percent of seasonal allergic rhinitic subjects reported more than three non-allergic triggers, compared with only 3% of non-allergic non-rhinitics (P < 0.01). Subjects over 35 years were more likely to report one or more non-allergic triggers, particularly tobacco smoke (P < 0.05). Allergic rhinitics reported more non-allergic symptom triggers than did non-allergic, non-rhinitics. As indexed by self-reported reactivity to non-specific physical and chemical triggers, both non-allergic rhinitics and a subset of allergic rhinitics may constitute susceptible populations for non-specific building-related illness.