Neuroanatomic organization of the parasympathetic bronchomotor system in developing sheep.
Neuroanatomic organization of the parasympathetic bronchomotor system in developing sheep.
复制标题
发育中的绵羊副交感支气管运动系统的神经解剖学组织。
DOI：
10.1152/ajpregu.1997.273.1.r121
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Velloff,CR
中科院分区：
文献类型：
--
作者：
PerezFontan,JJ;Velloff,CR
我们应用了两种互补的逆行标记技术来表征发育中的绵羊气管肌迷走神经支配的脑干神经元网络的组织。将霍乱毒素β亚单位注射到新生羔羊肌肉中产生的单神经元标记表明，气道迷走神经节前神经元仅位于歧义核和孤立束核。通过在羊胎中注射类似的Bartha株伪狂犬病毒产生的跨神经元标记表明，这些气道迷走神经节前神经元接受来自脑干区域的少数神经元的输入，这些神经元已知参与呼吸肌肉的运动前控制（腹侧呼吸组）、化学接受（孤立束核和腹侧髓表面）以及心血管和呼吸调节（中缝核）。腹外侧髓质，以及髓质和脑桥去肾上腺素能组)。我们的结论是，投射到气道平滑肌的迷走神经节前神经元在绵羊出生前就已经参与了呼吸控制。
We applied two complementary retrograde labeling techniques to characterize the organization of the brain stem neuronal network responsible for the vagal innervation of the trachealis muscle in developing sheep. Single neuronal labeling produced by injections of the beta-subunit of cholera toxin into the muscle in newborn lambs showed that airway vagal preganglionic neurons are located exclusively in the nucleus ambiguous and nucleus of the solitary tract. Transneuronal labeling produced by similar injections of the Bartha strain of the pseudorabies virus in sheep fetuses demonstrated that these airway vagal preganglionic neurons receive inputs from a small number of neurons in brain stem areas known to participate in premotor control of the respiratory muscles (ventral respiratory group), chemoreception (nucleus of the solitary tract and ventral medullary surface), and cardiovascular and respiratory regulation (raphe nuclei, ventrolateral medulla, and noradrenergic groups of the medulla and pons). We conclude that the vagal preganglionic neurons that project to airway smooth muscle are already integrated in the control of breathing before birth in sheep.