A polymerization model of chiasma interference and corresponding computer simulation.
A polymerization model of chiasma interference and corresponding computer simulation.
复制标题
交叉干扰的聚合模型及相应的计算机模拟。
DOI：
10.1093/genetics/126.4.1127
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发表时间：
1990
期刊：
影响因子：
3.3
通讯作者：
Mortimer,RK
中科院分区：
文献类型：
--
作者：
King,JS;Mortimer,RK
提出了一种交叉干扰模型，并在计算机上进行了模拟。该模型使用随机事件和聚合反应来调节染色体之间和沿线的减数分裂重组。该模型的计算机模拟生成了每个染色体臂上的交叉分布、事件沿染色体臂的位置、两个事件四分体中交叉之间的距离以及作为距离的函数的重合。模拟的结果与酿酒酵母和黑腹果蝇的X染色体的数据进行了比较。模拟表明，所提出的模型可以产生在遗传学和细胞学实验中观察到的重组的调节。虽然该模型与仅来自果蝇和酵母菌的数据进行了定量比较，但在这些物种中观察到的规则与在其他生物中观察到的重组规则定性上相似。
A model of chiasma interference is proposed and simulated on a computer. The model uses random events and a polymerization reaction to regulate meiotic recombination between and along chromosomes. A computer simulation of the model generates distributions of crossovers per chromosome arm, position of events along the chromosome arm, distance between crossovers in two-event tetrads, and coincidence as a function of distance. Outputs from the simulation are compared to data from Saccharomyces cerevisiae and the X chromosome of Drosophila melanogaster. The simulation demonstrates that the proposed model can produce the regulation of recombination observed in both genetic and cytological experiments. While the model was quantitatively compared to data from only Drosophila and Saccharomyces, the regulation observed in these species is qualitatively similar to the regulation of recombination observed in other organisms.