Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy
Cardiorespiratory and electrocardiographic effects of methadone or morphine in the perioperative period in anesthetized dogs with continuous rate infusion of propofol and submitted to ovariohysterectomy
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DOI：
10.5433/1679-0359.2017v38n1p209
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发表时间：
2017-01-01
影响因子：
0.5
通讯作者：
de Mattos Junior, Ewaldo
中科院分区：
文献类型：
--
作者：
Cintra, Priscila Pavini;Nishimori Duque, Celina Tie;de Mattos Junior, Ewaldo
本研究的目的是比较静脉注射美沙酮或吗啡对持续输注异丙酚麻醉犬的心电图和心肺功能的影响。本研究选用16只健康雌性杂种犬进行择期卵巢子宫切除术。随机分为两组，分别给予GME（美沙酮0.3 mg kg(- 1)，静脉注射）和GMO（吗啡0.3 mg kg(- 1)，静脉注射）。评估参数：心率（HR）、p波振幅（Ps和PmV）、p波和R波间隔（PR）、QRS持续时间（QRS）、R波振幅(R)、Q波和T波间隔持续时间（QT）、收缩压（SBP）、直肠温度（RT）、呼吸频率（RR）、二氧化碳末潮（ETCO2）和外周血氧合血红蛋白饱和度（SpO(2)）。术后镇痛采用Firth和Haldane（1999）提出的机械性伤害性刺激量表，救援镇痛采用视觉模拟量表。与GMO相比，GME的HR更低。P、PmV、PR、QRS、R、QT值均在正常范围内，无临床意义。两组患者呼吸暂停和ETCO2均升高。两组间镇痛效果无明显差异。由此可见，异丙酚麻醉犬术中静脉注射美沙酮与吗啡对心血管的影响相似，但使用美沙酮时需要辅助通气。此外，这两种药物都能促进术后6小时的镇痛。
The aims of this study were compare the electrocardiogram (ECG) and cardiopulmonary effects of methadone or morphine, both injected intravenously (IV) in dogs anesthetized with continuous infusion of propofol. Sixteen healthy female mongrel dogs were used in this study for elective ovariohysterectomy. The animals were allocated in random order into two groups assigned GME (methadone 0.3 mg kg(- 1), IV) or GMO (morphine 0.3 mg kg(- 1), IV). Parameters were evaluated: heart rate (HR), P-wave amplitude (Ps and PmV), interval between Ps and R waves (PR), QRS duration (QRS), R-wave amplitude (R), duration the interval between the Q and T waves (QT), systolic blood pressure (SBP), rectal temperature (RT), respiratory rate (RR), end tidal of carbon dioxide (ETCO2) and periferic oxyhemoglobin saturation (SpO(2)). Postoperative analgesia was assessed by mechanical nociceptive stimulus based on the scale proposed by Firth and Haldane (1999) and rescue analgesia based on the visual analogue scale. HR was lower in GME in relation to GMO. The P, PmV, PR, QRS, R and QT values remained within their normality tracks, showing no clinical importance. Apnea and ETCO2 increased in both groups. There was no difference between groups of the analgesic effects. It can be concluded that methadone and morphine promote similar cardiovascular effects after IV injection during surgery in dogs anesthetized with propofol by continuous rate infusion, however, when methadone used, assisted ventilation is required. In addition, both drugs promote postoperative analgesia until six hours.