BIOLOGICAL AND CULTURAL SOURCES OF FAMILIAL RESEMBLANCE IN PLASMA-LIPIDS - A COMPARISON BETWEEN NORTH-AMERICA AND ISRAEL - THE LIPID-RESEARCH-CLINICS-PROGRAM
BIOLOGICAL AND CULTURAL SOURCES OF FAMILIAL RESEMBLANCE IN PLASMA-LIPIDS - A COMPARISON BETWEEN NORTH-AMERICA AND ISRAEL - THE LIPID-RESEARCH-CLINICS-PROGRAM
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DOI：
10.1002/gepi.1370050103
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发表时间：
1988-01-01
影响因子：
2.1
通讯作者：
RIFKIND, BM
中科院分区：
文献类型：
--
作者：
BUCHER, KD;FRIEDLANDER, Y;RIFKIND, BM
使用路径分析研究了北美和以色列人群之间脂质和脂蛋白水平家族相似性决定因素的异质性。两个样本使用了共同的方案、相同的测量技术和相同的统计程序。在这两项研究中，遗传的遗传 (h2) 和文化 (c2) 决定因素对于所有脂质变量都很重要。总胆固醇（h2 = 0.61，c2 = 0.02）、低密度脂蛋白胆固醇（h2 = 0.59，c2 = 0.02）和高密度脂蛋白胆固醇（h2 = 0.55，c2 = 0.06）的遗传和文化遗传力在北美和以色列之间没有显着差异，而甘油三酯则存在显着差异（h2 = 0.41，c2）在北美，h2 = 0.07；在以色列，h2 = 0.61，c2 = 0.05）。描述家庭内部环境关系的路径模型的次要参数在两国之间有所不同。特别是，除了甘油三酯之外，以色列婚姻环境对所有性状的相关性都较高，并且父亲的环境对以色列后代环境对所有性状的影响更大。在这两个人群中，血浆脂质和脂蛋白的变化主要是由遗传因素和随机的未测量的环境因素解释的。研究发现，共同家庭环境的贡献很小，但具有统计意义。这可能是由于两国家庭环境决定因素分布的同质性。
Heterogeneity in determinants of familial resemblance of lipid and lipoprotein levels between populations in North America and Israel was investigated using path analysis. A common protocol, identical measurement techniques, and the same statistical procedures were used in the two samples. Both genetic (h2) and cultural (c2) determinants of inheritance were significant for all lipid variables in the two studies. Genetic and cultural heritability of total cholesterol (h2 = 0.61, c2 = 0.02), low-density lipoprotein cholesterol (h2 = 0.59, c2 = 0.02), and high-density lipoprotein cholesterol (h2 = 0.55, c2 = 0.06) did not differ significantly between North America and Israel, while there was a significant difference for triglyceride (h2 = 0.41, c2 = 0.07 in North America; h2 = 0.61, c2 = 0.05 in Israel). Secondary parameters of the path model describing intrafamilial environmental relationships differed between the two countries. In particular, there was a higher correlation between marital environments in Israel for all traits except triglyceride, and a larger effect of father''s environment on offspring''s environment in Israel for all traits. Within both populations, variation of plasma lipids and lipoproteins was mostly explained by genetic factors and random unmeasured environmental factors. The contribution of common family environment was found to be small, though statistically significant. This is probably due to homogeneity of the distribution of familial environmental determinants within both countries.