Effects of Hochuekkito combined with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease
Effects of Hochuekkito combined with pulmonary rehabilitation in patients with chronic obstructive pulmonary disease
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DOI：
10.3892/etm.2018.6837
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发表时间：
2018-12-01
影响因子：
2.7
通讯作者：
Hattori, Noboru
中科院分区：
文献类型：
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作者：
Hamada, Hironobu;Sekikawa, Kiyokazu;Hattori, Noboru
慢性阻塞性肺疾病（COPD）具有显著的全身性影响，如体重减轻，影响运动能力、健康相关生活质量（HRQOL）和生存。传统草药Hochuekkito （TJ-41）可以改善慢性阻塞性肺病患者的营养状况，减少全身炎症。然而，迄今为止，TJ-41对COPD患者肺康复（PR）的加性作用尚未得到全面的研究。本研究的目的是探讨TJ-41联合PR治疗COPD患者的疗效和安全性。33例慢性阻塞性肺病营养不良患者随机分为低强度运动组（TJ-41组）和非TJ-41组（对照组），为期12周。主要终点是6分钟步行距离（6MWD）的变化。次要结局包括身体组成、外周肌肉力量、改良医学研究委员会呼吸困难评分、呼吸困难视觉模拟评分（VAS）评分、疲劳VAS评分和COPD评估测试（CAT）评分的变化。治疗12周后，TJ-41组大鼠体重和理想体重百分比均显著升高(P
Chronic obstructive pulmonary disease (COPD) has significant systemic effects, such as weight loss, which affects exercise capacity, health-related quality of life (HRQOL) and survival. The traditional herbal medicine, Hochuekkito (TJ-41), improves the nutritional status and decreases systemic inflammation in patients with COPD. However, to date, the additive effect of TJ-41 on pulmonary rehabilitation (PR) in patients with COPD has not been researched comprehensively. The purpose of the present study was to investigate the efficacy and safety of adding TJ-41 to PR for patients with COPD. Thirty-three malnourished patients with COPD were randomly assigned to receive low-intensity exercise with (TJ-41 group) or without (control group) TJ-41 treatment for 12 weeks. The primary outcome was the change in the 6-min walk distance (6MWD). Secondary outcomes included changes in the body composition, peripheral muscle strength, modified Medical Research Council dyspnea score, visual analog scale (VAS) score for dyspnea, VAS score for fatigue and COPD assessment test (CAT) score. After the 12-week treatment, body weight and percent ideal body weight were significantly increased in the TJ-41 group (P