Roles of the oviduct in mammalian fertilization.
Roles of the oviduct in mammalian fertilization.
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DOI：
10.1530/rep-12-0279
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Avilés M
中科院分区：
文献类型：
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作者：
Coy P;García-Vázquez FA;Visconti PE;Avilés M
输卵管或输卵管是哺乳动物物种中每个新生命开始的解剖区域。经过长途旅行后，精子在输卵管的特定部位（壶腹）与卵母细胞相遇，发生受精。受精的成功取决于几个生物学过程，这些过程发生在交配前几个小时的输卵管中，并影响两个配子。从卵巢释放的雌激素和孕激素通过输卵管上皮中的基因组和非基因组途径协调一系列变化，影响基因表达、蛋白质组和其细胞分泌到输卵管腔的流体中。此外，新的调控分子正在被发现在输卵管生理和受精中发挥重要作用。本综述试图描述这些过程，建立一个全面的输卵管生理学地图，以更好地了解这个器官在生殖中的重要性。为此，配子运输，精子和卵母细胞在输卵管环境中的变化和其他配子和输卵管之间的相互作用进行了讨论，在该领域的最新出版物。
The oviduct or Fallopian tube is the anatomical region where every new life begins in mammalian species. After a long journey, the spermatozoa meet the oocyte in the specific site of the oviduct named ampulla, and fertilization takes place. The successful fertilization depends on several biological processes which occur in the oviduct some hours before this rendezvous and affect both gametes. Estrogen and progesterone, released from the ovary, orchestrate a series of changes by genomic- and non-genomic pathways in the oviductal epithelium affecting gene expression, proteome and secretion of its cells into the fluid bathing the oviductal lumen. In addition, new regulatory molecules are being discovered playing important roles in oviductal physiology and fertilization. The present review tries to describe these processes, building a comprehensive map of the physiology of the oviduct, to better understand the importance of this organ in reproduction. With this purpose, gamete transport, sperm and oocyte changes in the oviductal environment and other interactions between gametes and oviduct are discussed in light of recent publications in the field.