Diastereo- and Enantioselective Pd(II)-Catalyzed Additions of 2-Alkylazaarenes to N-Boc Imines and Nitroalkenes
Diastereo- and Enantioselective Pd(II)-Catalyzed Additions of 2-Alkylazaarenes to N-Boc Imines and Nitroalkenes
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DOI：
10.1021/ja3083494
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发表时间：
2012-11-07
影响因子：
15
通讯作者：
Lam, Hon Wai
中科院分区：
文献类型：
--
作者：
Best, Daniel;Kujawa, Szymon;Lam, Hon Wai
一种手性Pd(II)-双（恶唑啉）配合物在温和条件下可有效促进烷基杂环芳烃与N-Boc醛胺和硝基烯烃的首次非映对和对映选择性加成反应。对boc保护的产品进行脱保护，很容易产生高产量的胺。
A chiral Pd(II)-bis(oxazoline) complex was found to be highly effective in promoting the first direct diastereo- and enantioselective addition of alkylazaarenes to N-Boc aldimines and nitroalkenes under mild conditions. Deprotection of Boc-protected products proceeded readily to provide amines in high yields.