Differences between muscular receptors and neural receptors for cholecystokinin-octapeptide in the guinea-pig gallbladder.
Differences between muscular receptors and neural receptors for cholecystokinin-octapeptide in the guinea-pig gallbladder.
复制标题
豚鼠胆囊中胆囊收缩素八肽的肌肉受体和神经受体之间的差异。
DOI：
10.1016/0014-2999(87)90721-7
复制
发表时间：
1987
影响因子：
5
通讯作者：
J. Utsunomiya
中科院分区：
文献类型：
--
作者：
T. Takahashi;T. Yamamura;M. Kusunoki;M. Kantoh;Y. Ishikawa;J. Utsunomiya
为了研究豚鼠胆囊收缩素-八肽（CCK-OP）肌肉受体和神经受体的差异，我们研究了二丁基环GMP （dbc GMP）对CCK-OP引起的收缩和[3H]乙酰胆碱（ACh）释放的影响。10−3M dbc GMP显著降低CCK-OP（10−8M）诱发的收缩，而不影响肽诱导的[3H]乙酰胆碱释放。提示豚鼠胆囊中存在两种类型的CCK-OP受体（dbc gmp敏感肌受体和dbc gmp不敏感神经受体）。
To investigate the differences between muscular and neural receptors for cholecystokinin-octapeptide (CCK-OP) in the guinea-pig gallbladder, we studied the effects of dibutyryl cyclic GMP (dbc GMP) on CCK-OP-evoked contraction and [3H]acetylcholine (ACh) release. 10−3M dbc GMP significantly reduced CCK-OP (10−8M)-evoked contractions without affecting the peptide-induced [3H]ACh release. It is suggested that there are two types of CCK-OP receptors in the guinea-pig gallbladder (dbc GMP-sensitive muscular receptors and dbc GMP-insensitive neural receptors).