Correlation of continuously monitored regional cerebral blood flow and brain tissue oxygen
Correlation of continuously monitored regional cerebral blood flow and brain tissue oxygen
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DOI：
10.1007/s00701-004-0408-z
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发表时间：
2005-01-01
影响因子：
2.4
通讯作者：
Meixensberger, J
中科院分区：
文献类型：
--
作者：
Jaeger, M;Soehle, M;Meixensberger, J
背景本研究旨在探讨连续监测脑局部血流量（CBF）与脑组织氧分压（PtiO2）的关系。在严重蛛网膜下腔出血（n = 5）和创伤性脑损伤（n = 3）后，对8例患者进行了连续高级多模式神经监测，包括监测PtiO2（Licox，GMS）和CBF（QFlow，Hemedex），平均持续9.6天。使用柔性极谱PtiO2探针和热扩散CBF微探针测量参数。关于所有患者的整个监测期，数据表明CBF和PtiO2之间存在显著相关性（r = 0.36）。在PtiO2变化大于5mmHg的400个30分钟分析间期中，72%的间期的CBF与PtiO2之间存在强相关性（r > 0.6）。在19%的间隔中，观察到统计学上仍然显著的相关性（0.3 < r < 0.6）。在其余9%的时间内，未发现相关性（r < 0.3）。关于监测器械的临床稳定性，CBF监测系统允许在仅可能进行PtiO2监测的64%时间内监测CBF。非监测阶段主要是由于患者发热，当系统不允许监测，以避免大脑组织过热。这项研究表明CBF和PtiO2之间的相关性。PtiO2的水平似乎主要由局部CBF决定，因为在90%的发作中PtiO2的变化与CBF的同时变化相关。
Background. The purpose of this study was to investigate the relationship between continuously monitored regional cerebral blood flow (CBF) and brain tissue oxygen (PtiO2).Methods. Continuous advanced multimodal neuromonitoring including monitoring of PtiO2 (Licox, GMS) and CBF (QFlow, Hemedex) was performed in eight patients after severe subarachnoid haemorrhage (n = 5) and traumatic brain injury (n = 3) for an average of 9.6 days. Parameters were measured using a flexible polarographic PtiO2-probe and a thermal diffusion CBF-microprobe.Findings. Regarding the whole monitoring period in all patients, the data indicated a significant correlation between CBF and PtiO2 (r = 0.36). In 72% of 400 analysed intervals of 30 minutes duration with PtiO2 changes larger than 5 mmHg, a strong correlation between CBF and PtiO2 existed (r > 0.6). In 19% of intervals a still statistically significant correlation was observed (0.3 < r < 0.6). During the remaining 9% no correlation was found (r < 0.3). Regarding the clinical stability of the monitoring devices, the CBF monitoring system allowed monitoring of CBF in 64% of the time when PtiO2 monitoring was possible only. Phases of non-monitoring were mostly due to fever of the patient, when the system does not allow monitoring to avoid overheating of the cerebral tissue.Conclusions. This study suggests a correlation between CBF and PtiO2. The level of PtiO2 seems to be predominately determined by regional CBF, since changes in PtiO2 were correlated in 90% of episodes to simultaneous changes of CBF.