The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.
The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.
复制标题
11 号染色体的短臂是人类肿瘤中高甲基化的“热点”。
DOI：
10.1073/pnas.85.15.5693
复制
发表时间：
1988
影响因子：
11.1
通讯作者：
Baylin,SB
中科院分区：
文献类型：
--
作者：
deBustros,A;Nelkin,BD;Silverman,A;Ehrlich,G;Poiesz,B;Baylin,SB
Inactivation of normally expressed genes may play a role in the formation and/or progression of human cancers. Methylation of cytosine in DNA could potentially participate in such alterations of gene expression. Abnormalities in DNA methylation are a consistent feature of human neoplasms, and we now show that these include not only previously recognized widespread genomic hypomethylation, but also regional increases in gene methylation. A hot spot for abnormal methylation of C + G-rich areas has been detected on the short arm of chromosome 11 in an area known to harbor tumor suppressor genes. This change occurs consistently in common forms of human cancer and appears early during the transformation of cells with viruses including members of the human T-cell leukemia (HTLV) family. Furthermore, in one chromosome 11 gene examined, calcitonin, the increased methylation in somatic tumor cells coincides with the presence of an "inactive" chromatin pattern in the transcriptional regulatory area. The increased regional DNA methylation demonstrated may then participate in or mark chromosomal changes associated with gene inactivation events that are central to the genesis and/or progression of human cancers.
