A Network Meta-Analysis Comparing Effects of Various Antidepressant Classes on the Digit Symbol Substitution Test (DSST) as a Measure of Cognitive Dysfunction in Patients with Major Depressive Disorder.
A Network Meta-Analysis Comparing Effects of Various Antidepressant Classes on the Digit Symbol Substitution Test (DSST) as a Measure of Cognitive Dysfunction in Patients with Major Depressive Disorder.
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DOI：
10.1093/ijnp/pyx070
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发表时间：
2018-02-01
期刊：
影响因子：
--
通讯作者：
Larsen KG
中科院分区：
文献类型：
--
作者：
Baune BT;Brignone M;Larsen KG
重度抑郁症是一种常见的疾病，通常包括认知功能障碍。本研究对相关研究进行了系统的文献综述和网络荟萃分析，以评估抗抑郁药对重度抑郁症认知功能障碍的相对影响。检索MEDLINE、Embase、科克伦、CDSR和PsychINFO数据库、临床试验登记和相关会议摘要，以获得评估抗抑郁药/安慰剂对认知影响的随机对照试验。使用随机效应模型进行了一项比较抗抑郁药的网络荟萃分析。数据库检索检索到11337篇引文，其中来自103篇出版物的72项随机对照试验符合纳入标准。该综述确定了86项评估抗抑郁药对认知功能影响的认知测试。然而，数字符号替代测试，它针对多个认知领域，被认为是对变化敏感，是唯一的测试，在12个随机对照试验中使用，并允许构建一个稳定的网络适合网络荟萃分析。评估的干预措施包括选择性5-羟色胺再摄取抑制剂、降钙素-去甲肾上腺素再摄取抑制剂和其他非选择性5-羟色胺再摄取抑制剂/降钙素-去甲肾上腺素再摄取抑制剂。使用数字符号替代测试的网络荟萃分析显示，沃替西汀是唯一一种在数字符号替代测试中与安慰剂相比改善认知功能障碍的抗抑郁药{标准化平均差异：0.325（95% CI = 0.120; 0.529，P= 0.009}。与其他抗抑郁药相比，沃替西汀在数字符号替代试验中的有效性高于艾司西酞普兰、去甲替林、选择性5-羟色胺再摄取抑制剂和三环类抗抑郁药。这项研究强调了用于评估认知功能的措施的巨大差异。数字符号替代试验的结果表明，各种抗抑郁药对改善重度抑郁症患者的认知功能有不同的作用。
Major depressive disorder is a common condition that often includes cognitive dysfunction. A systematic literature review of studies and a network meta-analysis were carried out to assess the relative effect of antidepressants on cognitive dysfunction in major depressive disorder. MEDLINE, Embase, Cochrane, CDSR, and PsychINFO databases; clinical trial registries; and relevant conference abstracts were searched for randomized controlled trials assessing the effects of antidepressants/placebo on cognition. A network meta-analysis comparing antidepressants was conducted using a random effects model. The database search retrieved 11337 citations, of which 72 randomized controlled trials from 103 publications met the inclusion criteria. The review identified 86 cognitive tests assessing the effect of antidepressants on cognitive functioning. However, the Digit Symbol Substitution Test, which targets multiple domains of cognition and is recognized as being sensitive to change, was the only test that was used across 12 of the included randomized controlled trials and that allowed the construction of a stable network suitable for the network meta-analysis. The interventions assessed included selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and other non-selective serotonin reuptake inhibitors/serotonin-norepinephrine reuptake inhibitors. The network meta-analysis using the Digit Symbol Substitution Test showed that vortioxetine was the only antidepressant that improved cognitive dysfunction on the Digit Symbol Substitution Test vs placebo {standardized mean difference: 0.325 (95% CI = 0.120; 0.529, P=.009}. Compared with other antidepressants, vortioxetine was statistically more efficacious on the Digit Symbol Substitution Test vs escitalopram, nortriptyline, and the selective serotonin reuptake inhibitor and tricyclic antidepressant classes. This study highlighted the large variability in measures used to assess cognitive functioning. The findings on the Digit Symbol Substitution Test indicate differential effects of various antidepressants on improving cognitive function in patients with major depressive disorder.
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影响因子：
6.6
作者：
Buchanan, Robert W.;Keefe, Richard S. E.;Marder, Stephen R.
通讯作者：
Marder, Stephen R.
DOI：
10.1080/13803395.2013.824071
发表时间：
2013-08-19
影响因子：
2.2
作者：
Baune, Bernhard T.;Li, Xi;Beblo, Thomas
通讯作者：
Beblo, Thomas
DOI：
10.1177/0269881114543719
发表时间：
2014-10
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Dale E;Zhang H;Leiser SC;Xiao Y;Lu D;Yang CR;Plath N;Sanchez C
通讯作者：
Sanchez C
DOI：
10.1017/s1461145714000546
发表时间：
2014-10
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
McIntyre RS;Lophaven S;Olsen CK
通讯作者：
Olsen CK
DOI：
10.1038/npp.2015.52
发表时间：
2015-07
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Mahableshwarkar AR;Zajecka J;Jacobson W;Chen Y;Keefe RS
通讯作者：
Keefe RS