On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines.
On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines.
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DOI：
10.1039/c1cc11870f
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发表时间：
2011-06
影响因子：
4.9
通讯作者：
C. Roe;Toni Moragas Solá;Leonid Sasraku-Neequaye;H. Hobbs;I. Churcher;D. Macpherson;R. Stockman
中科院分区：
文献类型：
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作者：
C. Roe;Toni Moragas Solá;Leonid Sasraku-Neequaye;H. Hobbs;I. Churcher;D. Macpherson;R. Stockman
研究了S-均三甲苯基亚磺酰亚胺与Grignard试剂、碘化三甲基锍和溴化S-烯丙基四氢噻吩衍生的叶立德以及氮杂-Darfonite歧管反应合成手性胺和氮杂环丙烷的应用，以高产率和优异的立体选择性方便地合成了各种高度取代的手性胺和氮杂环丙烷。
The synthetic utility of S-mesitylsulfinimines for the synthesis of chiral amines and aziridines was examined through their reactions with Grignard reagents, with the ylides derived from trimethylsulfonium iodide and S-allyl-tetrahydrothiophenium bromide and through an aza-Darzens manifold, affording convenient access to a diverse range of highly substituted chiral amines and aziridines in high yields and excellent stereoselectivities.