Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction
Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction
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DOI：
10.1006/bbrc.2001.4493
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发表时间：
2001-03-16
影响因子：
3.1
通讯作者：
Abe, Y
中科院分区：
文献类型：
--
作者：
Fukui, T;Yoshiyama, M;Abe, Y
近年来的研究表明，氧化应激在心血管疾病中起着重要作用。NADPH氧化酶是超氧阴离子的主要来源之一，并且是动脉粥样硬化的起始和发展的候选者，动脉粥样硬化涉及血管重塑。然而，NADPH氧化酶与心室重塑的相关性尚未得到很好的表征。这是第一次报告表明，p22-phox和gp 91-phox的表达，NADPH氧化酶的基本组成部分，在心肌梗死后的梗死部位增加。在梗塞部位，指示脂质过氧化水平的硫代巴比妥酸反应物质的水平和核因子-κ B（NF-κ B）DNA结合活性也增加。我们的研究结果表明，NADPH氧化酶的表达增加，可能有影响左心室重构通过增加氧化还原敏感的NF-κ B DNA结合活性以及脂质过氧化水平。(C)北京：科学出版社.
Recent studies have shown that oxidative stress plays an important role in cardiovascular diseases. NADPH oxidase is one of the major sources of superoxide anions and a candidate for the initiation and development of atherosclerosis, which involves the remodeling of vasculature. However, the relevance of NADPH oxidase in ventricular remodeling has not been well-characterized. This is the first report showing that the expression of p22-phox and gp91-phox, essential components of NADPH oxidase, are increased in the infarcted sites after myocardial infarction. The levels of thiobarbituric acid reactive substance, which indicates the lipid peroxidation level, and nuclear factor-kappaB (NF-kappaB) DNA binding activity are also increased in infarcted sites. Our results suggest that the increased expression of NADPH oxidase may have an effect on left ventricular remodeling by increasing the redox-sensitive NF-kappaB DNA binding activity as well as the lipid peroxidation level. (C) 2001 Academic Press.