Estimation of variation among individuals of biological half-time of cadmium calculated from accumulation data.
Estimation of variation among individuals of biological half-time of cadmium calculated from accumulation data.
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DOI：
10.1006/enrs.1995.1005
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发表时间：
1995
影响因子：
8.3
通讯作者：
Minoru Sugita;K. Tsuchiya
中科院分区：
文献类型：
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作者：
Minoru Sugita;K. Tsuchiya
对于重金属，许多使用动物的实验研究表明，通过施用重金属，生物半衰期（BHT）短至1年或更短。然而，Tsuchiya和Sugita设计了一种新颖的方法，并首次报道了镉（Cd）的长期BHT的可能性，该BHT是通过使用微分方程的非线性回归分析，根据镉在死后人体器官和组织中的累积量按年龄计算的。根据他们的报告，肾脏中Cd BHT的估计值为12.1-22.7年。估计的Cd BHT是点估计量。Cd BHT的点估计值已被不加区别地用于推导一般人群中工作环境或食品空气中Cd的安全水平，而不考虑Cd BHT的个体差异。在本研究中，估计镉BHT的个体之间的变化范围从几年到至少100年的肾脏。因此，不应盲目地使用根据数学计算的估计平均BHT来推导镉暴露的安全水平。
For heavy metals, many experimental studies using animals have revealed short biological half-times (BHTs) to be 1 year or less by administration of heavy metals. Tsuchiya and Sugita, however, devised an original method and first reported the possibility of a long BHT for cadmium (Cd) calculated from Cd accumulation in postmortem human organs and tissues by age using a nonlinear regression analysis employing a differential equation. According to their reports, the estimated values of Cd BHT were 12.1-22.7 years in the kidney. The estimated Cd BHTs are point estimators. The point estimator of Cd BHT has been used indiscriminately to derive safety levels for Cd in the air of work environments or foodstuffs in the general population without taking into consideration individual variation of Cd BHT. In the present study, the estimated variation among individuals of Cd BHT ranges from a few years to at least 100 years in the kidney. It is concluded that the estimated average BHT according to mathematical calculation should not be used indiscriminately to derive the safety level of cadmium exposure.