ONTOGENY OF THE ENHANCED BEHAVIORAL-RESPONSE TO AMPHETAMINE IN AMPHETAMINE-PRETREATED RATS
ONTOGENY OF THE ENHANCED BEHAVIORAL-RESPONSE TO AMPHETAMINE IN AMPHETAMINE-PRETREATED RATS
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DOI：
10.1007/bf02244610
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发表时间：
1990-01-01
影响因子：
3.4
通讯作者：
HOLSON, RR
中科院分区：
文献类型：
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作者：
KOLTA, MG;SCALZO, FM;HOLSON, RR
反复给成年大鼠安非他明的结果在增强行为反应，随后安非他明曝光。这些实验的目的是确定最早的年龄时，行为敏感安非他明可以检测到。对出生后1、7、21或49天（PND）的两种性别大鼠（n = 6-8/组）进行d-硫酸苯丙胺（5 mg/kg）或盐水SC注射，每天两次，连续5天。定型行为和自发活动响应的挑战剂量的d-苯丙胺（2.5毫克/公斤），或盐水，IP，进行了评估，共90分钟，最后一次剂量的预处理后15天。安非他明诱导的刻板行为显着增强时，安非他明预处理开始在PND 49，但不是在PND 1，7或21岁的早期。这种影响没有明显的性别差异。相应地，安非他明诱导的自发活动减少，在两个性别的相同年龄组（PND 49），但不提前预处理组相比，盐水预处理的大鼠。这些结果表明，安非他明致敏可能是一个后期发展的影响，一个发生在出生后第3周的某个时候。
Repeated administration of amphetamine to adult rats results in enhanced behavioral responses to subsequent amphetamine exposure. These experiments were designed to determine the earliest age at which behavioral sensitization to amphetamine could be detected. Rats from both sexes (n = 6-8/group) at ages of 1, 7, 21 or 49 postnatal days (PNDs) were injected with either d-amphetamine sulfate (5 mg/kg) or saline, SC, twice daily for 5 consecutive days. Stereotyped behavior and locomotor activity responses to a challenge dose of d-amphetamine (2.5 mg/kg), or saline, IP, were assessed for a total of 90 min, 15 days after the last dose of pretreatment. Amphetamine-induced stereotyped behavior was significantly enhanced only when amphetamine pretreatment was initiated at PND 49, but not at the earlier ages of PND 1, 7 or 21. There was no apparent sex difference in this effect. Correspondingly, amphetamine-induced locomotor activity was reduced in both sexes of the same age group (PND 49), but not in groups pretreated earlier, when compared to the saline-pretreated rats. These results suggest that amphetamine sensitization may be a late-developing effect, one which occurs sometime after the 3rd week of postnatal life.