Tenascin immunoreactivity in lung tumors.
Tenascin immunoreactivity in lung tumors.
复制标题
肺部肿瘤中腱蛋白的免疫反应性。
DOI：
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复制
发表时间：
1993
影响因子：
3.5
通讯作者：
V.
中科院分区：
文献类型：
--
作者：
Y. Soini;P. Pääkkö;K. Nuorva;D. Kamel;A. Linnala;Ismo Virtanen;V.
分析了生腱蛋白免疫反应性在非肿瘤性肺组织、良性肺肿瘤和不同类型肺癌中的分布。在非肿瘤性肺组织中，在支气管上皮和内皮细胞的基底膜、平滑肌细胞和支气管软骨中可以观察到生腱蛋白。在各种组织学类型的所有癌的基质中都观察到强生腱蛋白免疫反应性。鳞状细胞癌基质中的染色强度强于其他类型肺癌基质中的染色强度。在 27 例鳞状细胞癌中的 10 例中，在肿瘤细胞亚群中也可以观察到颗粒状胞质内反应。在 27 种腺癌中的 2 种以及两种腺鳞癌中观察到类似的胞质内反应性。在其他类型的肺肿瘤中，单个细胞不具有胞浆内腱蛋白，除了一例平滑肌瘤，其表现出弱的、线性的胞浆内腱蛋白反应性。在肺错构瘤中，在肿瘤的软骨成分和支气管上皮的基底膜区域中可以看到生腱蛋白。在类癌肿瘤中，基质显示出微弱的肌腱蛋白阳性。这些结果表明生腱蛋白在肺癌的基质中广泛表达。一部分肺癌还表达胞浆内生腱蛋白免疫反应性，表明肿瘤细胞可能能够合成生腱蛋白。然而，在肺部，生腱蛋白阳性并不限于恶性肿瘤，非肿瘤性肺实质和一些良性肺部肿瘤中存在生腱蛋白就证明了这一点。
The distribution of tenascin immunoreactivity was analyzed in nonneoplastic lung tissue, benign lung tumors, and different types of lung carcinomas. In nonneoplastic lung tissue, tenascin could be observed in the basement membranes of the bronchial epithelium and endothelial cells, smooth muscle cells, and bronchial cartilage. Strong tenascin immunoreactivity was seen in the stroma of all the carcinomas of various histologic types. The staining intensity was stronger in the stroma of squamous cell carcinomas than in the stroma of the other types of lung carcinomas. In 10 of 27 squamous cell carcinomas, a granular intracytoplasmic reactivity could also be observed in a subpopulation of tumor cells. Similar intracytoplasmic reactivity was observed in 2 of 27 adenocarcinomas and in both adenosquamous carcinomas. In other types of lung tumors, individual cells did not have intracytoplasmic tenascin, except for one case of leiomyoma, which showed a weak, linear, intracytoplasmic tenascin reactivity. In lung hamartomas, tenascin could be seen in the cartilaginous component of the tumor and in the areas of basement membranes of the bronchial epithelium. In the carcinoid tumors, the stroma displayed a faint positivity for tenascin. These results show that tenascin is widely expressed in the stroma of lung carcinomas. A proportion of lung carcinomas also expressed intracytoplasmic tenascin immunoreactivity, suggesting that tumor cells may be able to synthesize tenascin. In the lung, tenascin positivity is not, however, restricted to malignant neoplasms, as evidenced by the presence of tenascin in nonneoplastic lung parenchyma and in some benign lung tumors.
腱蛋白在人子宫内膜和子宫内膜腺癌中的表达。
DOI：
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发表时间：
1990
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Vollmer,G;Siegal,GP;Chiquet-Ehrismann,R;Lightner,VA;Arnholdt,H;Knuppen,R
通讯作者：
Knuppen,R
DOI：
10.1146/annurev.cb.05.110189.000443
发表时间：
1989-01-01
期刊：
ANNUAL REVIEW OF CELL BIOLOGY
影响因子：
--
作者：
ERICKSON, HP;BOURDON, MA
通讯作者：
BOURDON, MA