Peripheral Lewy body pathology in Parkinson's disease and incidental Lewy body disease: Four cases
Peripheral Lewy body pathology in Parkinson's disease and incidental Lewy body disease: Four cases
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DOI：
10.1016/j.jns.2011.06.003
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发表时间：
2011-11-15
影响因子：
4.4
通讯作者：
Duda, John E.
中科院分区：
文献类型：
--
作者：
Del Tredici, Kelly;Duda, John E.
Lewy病理（LP）在自主神经系统组织内的积累最近受到越来越多的关注，作为Lewy神经变性的可能诱导部位和早期帕金森病（PD）生物标志物的活检材料的可能来源。在这里，我们描述LP积累在各种组织中涉及周围自主神经系统神经元在三个PD病例和一个偶发性路易体病的情况下。研究结果强调了功能性神经解剖系统内病理检查的价值，特别是路易神经突（LNs）在PD病理生理学中的重要性。由爱思唯尔公司出版
The accumulation of Lewy pathology (LP) within autonomic nervous system tissues has received increased attention recently as a possible induction site for Lewy neurodegeneration and a possible source of biopsy material for biomarkers of early Parkinson's disease (PD). Here, we describe LP accumulation within various tissues involving peripheral autonomic nervous system neurons in three PD cases and one case of incidental Lewy body disease. Findings highlight the value of examining pathology within functional neuroanatomical systems and particularly the importance of Lewy neurites (LNs) in the pathophysiology of PD. Published by Elsevier B.V.