Biologically active polycations, 4. Synthesis and antimicrobial activity of poly(trialkylvinylbenzylammonium chloride)s†
Biologically active polycations, 4. Synthesis and antimicrobial activity of poly(trialkylvinylbenzylammonium chloride)s†
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DOI：
10.1002/macp.1984.021850503
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发表时间：
1984-05
影响因子：
2.5
通讯作者：
T. Ikeda;S. Tazuke;Yasuzou Suzuki
中科院分区：
文献类型：
--
作者：
T. Ikeda;S. Tazuke;Yasuzou Suzuki
制备了不同结构的聚（三烷基-3-（和4-）乙烯基苄基氯化铵），并采用常规平板法和活菌计数法对其抗菌活性进行了评价。它们通常对革兰氏阳性菌如枯草芽孢杆菌和金黄色葡萄球菌比对革兰氏阴性菌如大肠杆菌、产气杆菌和铜绿假单胞菌更有活性。研究发现具有最长烷基链（十二烷基）的化合物表现出特别高的活性，这归因于化合物疏水性增加对活性的贡献。最重要的发现是，聚合物进行了讨论和解释，在他们的更大的贡献，每一个基本过程中的杀菌行动：他们有利于吸附到细菌细胞表面和细胞质膜，随后破坏其完整性。
Various poly(trialkyl-3-(and 4-)vinylbenzylammonium chloride)s were prepared and their antibacterial activities were assessed by the conventional spread plate method and the viable counting method. They are in general more active against Gram-positive bacteria such as Bacillus subtilis and Staphylococcus aureus than against Gram-negative bacteria such as Escherichia coli, Aerobacter aerogenes and Pseudomonas aeruginosa. Compounds with the longest alkyl chain studied (dodecyl) were found to exhibit particularly high activity, and this was ascribed to the contribution of the increased hydrophobicity of the compounds to the activity. The most significant finding was that the polymers was discussed and interpreted in terms of their greater contribution to each elementary process in the cidal action: their favored adsorption onto the bacterial cell surface and the cytoplasmic membrane with subsequent disruption of its integrity.