Pain-related neurons in the human cingulate cortex
Pain-related neurons in the human cingulate cortex
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DOI：
10.1038/8065
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发表时间：
1999-05-01
影响因子：
25
通讯作者：
Dostrovsky, JO
中科院分区：
文献类型：
--
作者：
Hutchison, WD;Davis, KD;Dostrovsky, JO
尽管人们普遍认为皮质参与疼痛感知，但没有直接证据表明存在对人类有害或疼痛刺激做出反应的皮质神经元。动物的解剖学和神经生理学研究以及人类的脑成像和诱发电位研究表明，前扣带皮层 (ACC) 是处理与疼痛 1、2、3、4、5、6、7 相关的感觉信息的重要区域。我们现在已经确定了 ACC 中的单个神经元，它们可以选择性地响应疼痛的热和机械刺激，支持 ACC 在疼痛感知中的作用。
Although it is widely accepted that the cortex participates in pain perception, there is no direct evidence for the existence of cortical neurons that respond to noxious or painful stimuli in humans. Anatomical and neurophysiological studies in animals as well as brain imaging and evoked potential studies in humans suggest that the anterior cingulate cortex (ACC) is an important area for processing sensory information related to pain 1, 2, 3, 4, 5, 6, 7. We have now identified single neurons in ACC that respond selectively to painful thermal and mechanical stimuli, supporting a role for the ACC in pain perception.