Extended immunologic and genetic lineage of mammary analogue secretory carcinoma of salivary glands
Extended immunologic and genetic lineage of mammary analogue secretory carcinoma of salivary glands
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唾液腺乳腺类似分泌癌的扩展免疫学和遗传谱系。
DOI：
10.1016/j.humpath.2016.09.001
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发表时间：
2016-12-01
期刊：
影响因子：
3.3
通讯作者：
Rao, Qiu
中科院分区：
文献类型：
--
作者：
Ni, Hao;Zhang, Xue-ping;Rao, Qiu
摘要涎腺类乳腺分泌癌是一种新近发现的肿瘤。为了探索一种更实用和方便的免疫组化方法来区分MASC与其他来源于唾液腺的肿瘤，以及扩大MASC的免疫和遗传谱系，我们研究了17 MASC的临床病理，免疫组化和分子分析。腺泡细胞癌18例，腺样囊性癌18例，粘液表皮样癌22例，基底细胞腺癌14例。17个MASCs具有相似的结构，不仅具有管腔内或细胞内分泌，而且具有低级别囊泡核。此外，它们均为S-100和SOX-10免疫反应性，而17例中仅3例表现出加塔-3和P63反应性，17例中4例为CD 117局灶性阳性。荧光原位杂交检测10例ETV 6易位，2例ETV 6完整。我们的数据提出了一个联合的免疫组化面板，以区分MASC从其他肿瘤产生的唾液腺和扩大免疫和遗传谱系的MASC。(C)2016 Elsevier Inc. All rights reserved.
Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 MASCs using clinicopathologic, immunohistochemical, and molecular analyses. Eighteen cases of acinic cell carcinoma, 18 cases of adenoid cystic carcinoma, 22 cases of mucoepidermoid carcinoma, and 14 cases of basal cell adenocarcinoma were brought in for comparison. Seventeen MASCs shared similar architectures with not only intraluminal or intracellular secretion but also low-grade vesicular nuclei. In addition, they were all immunoreactive for S-100 and SOX-10, whereas only 3 of 17 demonstrated reactivity for GATA-3 and P63, and 4 of 17 were focally positive for CD117. ETV6 translocation was detected in 10 cases by fluorescence in situ hybridization, whereas intact ETV6 was noted in 2 cases. Our data proposed a combined immunohistochemical panel to distinguish MASC from other tumors arising from salivary glands and expanded the immunologic and genetic lineage of MASC. (C) 2016 Elsevier Inc. All rights reserved.