The first case of systemic lupus erythematosus (SLE) triggered by COVID-19 infection
The first case of systemic lupus erythematosus (SLE) triggered by COVID-19 infection
复制标题
DOI：
10.26355/eurrev_202009_23060
复制
发表时间：
2020-01-01
影响因子：
3.3
通讯作者：
Boverio, R.
中科院分区：
文献类型：
--
作者：
Bonometti, R.;Sacchi, M. C.;Boverio, R.
2019冠状病毒病（COVID-19）是由一种新出现的冠状病毒SARS-CoV-2引起的呼吸道感染。急性期之后可能是第二个阶段，实际上尚未完全了解，但可能与自身免疫激活有关。目前尚不可能明确定义免疫学发现与病理学症状之间的关联，然而，本病例报告描述了一例患者在COVID-19感染后出现自身免疫抗体，其持续时间长于病毒期。根据EULAR 2019标准，这些抗体可能导致我们患者显示的多种病理临床表现，可归类为系统性红斑狼疮（SLE）。SLE可能是COVID-19引发的可能的慢性风湿性疾病之一，这是文献中实际描述的第一例SLE伴血管炎。
Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, SARS-CoV-2. The acute phase may be followed by a second phase actually not yet completely understood but probably associated to an autoimmune activation. At the moment is not possible to clearly define an association between immunological findings and pathological symptoms, however, this case report describes the case of a patient who following COVID-19 infection development autoimmune antibodies who persist in time longer than viral phase. Those antibodies can be responsible for the multi pathological clinical picture showed from our patient that, according to EULAR 2019 criteria, could be classified as systemic lupus erythematosus (SLE). SLE is probably one of the possible chronic rheumatologic diseases triggers by COVID-19 and this is the first case of SLE with vasculitis actually described in literature.