The biphasic intraocular pressure response of rabbits to epinephrine.
The biphasic intraocular pressure response of rabbits to epinephrine.
复制标题
家兔对肾上腺素的双相眼压反应。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
G. Krieglstein
中科院分区：
文献类型：
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作者：
M. Langham;G. Krieglstein
本文研究了清醒家兔每日局部应用次大剂量肾上腺素对瞳孔和眼内压的反应。在第一天，肾上腺素引起瞳孔迅速扩大，这先于眼内压的长期升高。在第二天和随后的几天，应用相同剂量的肾上腺素增加了瞳孔反应的持续时间，并在所有治疗的眼睛中引起双相压力反应;眼内压最初升高持续2 - 4小时，随后眼内压降低至低于初始值，持续超过24小时。β-受体拮抗剂普萘洛尔和α-受体拮抗剂酚苄明分别引起肾上腺素引起的高血压反应的小幅度和大幅度降低。酚苄明，而不是普萘洛尔，也抑制瞳孔扩张和肾上腺素的肿胀反应。局部给药酚苄明强烈抑制肾上腺素的高血压反应，但不受影响的瞳孔反应。
A study has been made of the pupillary and intraocular pressure responses of conscious rabbits to daily topical applications of submaximal doses of epinephrine. On the first day, epinephrine caused rapid pupil dilation which preceded a prolonged -ecrease of intraocular pressure. On the second and subsequent days, the application of the same dose of epinephrine increased the duration of the pupillary response and caused a biphasic pressure response in all treated eyes; an initial increase of intraocular pressure lasting two to four hours followed by decrease of intraocular pressure below the initial value which lasted for more than twenty-four hours. The beta-receptor antagonist, propranolol, and the alpha-receptor antagonist, phenoxybenzamine, caused small and large reductions, respectively, in the hypertensive response to epinephrine. Phenoxybenzamine, but not propranolol, also inhibited the pupil dilation and the hypotensive response to epinephrine. Topical administration of phenoxybenzamine strongly inhibited the hypertensive response to epinephrine but left unaffected the pupillary response.