Peak assignment in localized H-1 MR spectra of human muscle based on oral creatine supplementation
Peak assignment in localized H-1 MR spectra of human muscle based on oral creatine supplementation
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DOI：
10.1002/mrm.1910370202
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发表时间：
1997-02-01
影响因子：
3.3
通讯作者：
Boesch, C
中科院分区：
文献类型：
--
作者：
Kreis, R;Koster, M;Boesch, C
人骨骼肌的H-1-MR谱的特征峰分裂由于偶极耦合。定量差光谱在双盲交叉试验测试口服肌酸补充剂显示，大多数的共振受偶极耦合可以分配给肌酸和/或磷酸肌酸。在两种不同的骨骼肌中进行分配，并通过在偶极分裂消失的魔角处的测量来证实。数值光谱模拟表明，所观察到的光谱是一致的部分平均偶极耦合亚甲基和甲基质子（磷酸）肌酸。分子动力学的可能性质导致不完全偶极平均进行了讨论。
H-1-MR spectra of human skeletal muscle feature peak splittings due to dipolar coupling. Quantitative difference spectroscopy in a double-blind cross-over trial testing oral creatine supplementation revealed that most of the resonances affected by dipolar coupling can be assigned to creatine and/or phosphocreatine. The assignment was performed in two different skeletal muscles and confirmed by measurements at the magic angle where dipolar splittings vanish. Numerical spectral simulations revealed that the observed spectra are consistent with partly-averaged dipolar coupling among methylene and methyl protons of (phospho)creatine. The possible nature of the molecular dynamics leading to incomplete dipolar averaging is discussed.