The Software Crisis of Synthetic Biology
The Software Crisis of Synthetic Biology
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DOI：
10.1101/041640
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
S. Valverde;M. Porcar;J. Peretó;R. Solé
中科院分区：
文献类型：
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作者：
S. Valverde;M. Porcar;J. Peretó;R. Solé
在15年的时间里，合成生物学(SB)已经从概念验证设计发展到几项旗舰成就。标准化工作仍在进行中，模块化和正交性等基本工程概念在生物学中仍存在争议，从计算机模型进行预测仍然不可靠。到目前为止，还没有人试图深入描述SB中生物块重新使用的模式。我们比较了两个不同技术网络的拓扑组织，一个与标准的大型软件库相关，另一个由标准生物部件注册中心(RSBP)提供。我们的结果强烈地表明，软件工程，而不是工业工程，是最接近某人的复杂系统。在这两种情况下，将标准或准标准零部件组装与修补结合起来可能与成功并不冲突。
In fifteen years, Synthetic Biology (SB) has moved from proof-of-concept designs to several flagship achievements. Standardisation efforts are still under way, basic engineering concepts such as modularity and orthogonality are still controversial in biology, and making predictions from computer models is still unreliable. A deep characterization in the pattern of re-use of biological blocks in SB has not been attempted to date. We have compared the topological organisation of two different technological networks, one associated to a standard, large-scale software repository and the second provided by the Registry of Standard Biological Parts (RSBP). Our results strongly suggest that software engineering, and not industrial engineering, is the closest complex system to SB. In both cases, combining standard or quasi-standard components assembly with tinkering may not be at odds with success.