The synergism of MCL1 and glycolysis on pediatric acute lymphoblastic leukemia cell survival and prednisolone resistance
The synergism of MCL1 and glycolysis on pediatric acute lymphoblastic leukemia cell survival and prednisolone resistance
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DOI：
10.3324/haematol.2013.093823
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发表时间：
2013-12-01
期刊：
影响因子：
10.1
通讯作者：
den Boer, Monique L.
中科院分区：
文献类型：
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作者：
Aries, Ingrid M.;Hansen, Bo R.;den Boer, Monique L.
体外和体内对泼尼松龙的耐药性可预测儿童前体B急性淋巴细胞白血病的不良预后。抵抗的原因仍然知之甚少。在这项研究中，我们观察到泼尼松龙敏感患者白血病细胞的泼尼松龙暴露使抗凋亡MCL1蛋白水平降低2.9倍，而泼尼松龙耐药患者白血病细胞的MCL1蛋白表达不受影响（P
In vitro and in vivo resistance to prednisolone are predictive for an adverse prognosis in pediatric precursor B-acute lymphoblastic leukemia. Causes of resistance are still poorly understood. In this study, we observed that prednisolone exposure of prednisolone-sensitive patients' leukemic cells decreased anti-apoptotic MCL1 protein levels by 2.9-fold, while MCL1 protein expression in prednisolone-resistant leukemic patients' cells was unaffected (P