Alcohol consumption in the elderly and risk of dementia related death - a Norwegian prospective study with a 17-year follow-up
Alcohol consumption in the elderly and risk of dementia related death - a Norwegian prospective study with a 17-year follow-up
复制标题
DOI：
10.3109/00207454.2014.997876
复制
发表时间：
2016-02-01
影响因子：
2.2
通讯作者：
Strand, Bjorn Heine
中科院分区：
文献类型：
--
作者：
Ormstad, Heidi;Rosness, Tor A.;Strand, Bjorn Heine
目的：本研究的目的是在考虑相关混杂因素和中介因素的情况下，确定饮酒与痴呆相关死亡风险之间的关系。材料和方法：数据来自挪威一项前瞻性研究，随访17年。研究人群包括来自挪威队列（CONOR）的25,635名年龄在60至80岁之间的参与者。采用Cox回归研究酒精使用与痴呆相关死亡之间的关系。结果：近一半（12,139）的研究人群在随访期间死亡，其中1,224人在死亡证明上被诊断为痴呆症。在完全调整模型中，不饮酒者患痴呆相关死亡的风险显著高于每月饮酒一次的个体（HR = 1.33, 95% CI = 1.14-1.56, p < 0.001）。缺乏饮酒信息的受访者（占研究人群的5%）与痴呆症相关死亡的风险最高（HR = 1.60, 95% CI = 1.28-2.00, p < 0.001），与饮酒相关原因（HR = 1.41, 95% CI = 1.03-1.93, p = 0.031）和其他原因（HR = 1.32, 95% CI = 1.21-1.43, p < 0.001）造成的死亡率也显著高于每月饮酒不超过一次的受访者。结论：这些发现表明，在调整了相关混杂因素后，老年戒酒者患痴呆症相关死亡的风险明显高于饮酒者。然而，由于饮酒频率信息的缺失，在解释数据时应注意，因为这一缺失的群体可能在研究队列中有很大比例的重度饮酒者。
Purpose: The aim of this study was to determine the association between alcohol intake and risk of dementia related death, taking into account relevant confounding and mediating factors. Materials and Methods: Data was obtained from a Norwegian prospective study with a 17-year follow-up. The study population comprised 25,635 participants aged between 60 and 80years at the time of examination from the Cohort of Norway (CONOR). Cox regression was used to investigate the association between alcohol use and dementia related death. Results: Nearly half (12,139) of the study population died during follow-up, of which 1,224 had a diagnosis of dementia on their death certificate. The risk of dementia related death was significantly higher among abstainers than among individuals that drank alcohol once per month (HR = 1.33, 95% CI = 1.14-1.56, p < 0.001, in a fully adjusted model). Respondents with missing information regarding alcohol consumption (representing 5% of the study population) had the highest risk of dementia related death (HR = 1.60, 95% CI = 1.28-2.00, p < 0.001) and also significantly higher mortality rates due to alcohol-related causes (HR = 1.41, 95% CI = 1.03-1.93, p = 0.031) and other causes (HR = 1.32, 95% CI = 1.21-1.43, p < 0.001), all compared to those drinking alcohol no more than once per month. Conclusion: These findings suggest that the risk of dementia related death is significantly higher among elderly abstainers than among those who drink alcohol, after adjusting for relevant confounders. However, care should be taken in interpretation of data due to missing information on drinking frequency, as this missing-group might have a large share of the heavy drinkers in the study cohort.