Unipolar depressive disorders have a common genotype
Unipolar depressive disorders have a common genotype
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DOI：
10.1016/j.jad.2008.12.004
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发表时间：
2009-09-01
影响因子：
6.6
通讯作者：
Oien, Per Anders
中科院分区：
文献类型：
--
作者：
Edvardsen, Jack;Torgersen, Svenn;Oien, Per Anders
背景资料：本研究的目的是评估遗传因素、共同环境因素和独特环境因素在单相重性抑郁症（MD）病因学中的作用，并调查是否可以将单相抑郁症：MD、非典型抑郁/抑郁NOS、恶劣心境和抑郁适应障碍视为潜在遗传共性的各种表达。方法：一个由同性单卵双胞胎和双卵双胞胎组成的样本来自医院和门诊登记处（N = 303）。DSM-III-R标准通过个人访谈进行评估。143名先证者符合一种或另一种单相抑郁障碍的标准。交叉表用于比较MD和MD与其他单相抑郁障碍的不同组合的一致率。用生物统计学模型拟合的相关性和遗传度（h（2））的估计值进行了分析。结果：对于MD和MD与其他单相抑郁障碍的所有不同组合，MZ-对的一致率高于DZ对。观察到MD和其他单极疾病之间的交叉一致性。在所有情况下，除了当MD被认为是单独的情况下，MZ对之间的责任的相关性的两倍以上的DZ对之间的责任的相关性。MD的遗传度为0.42，MD +非典型抑郁症的遗传度为0.51，MD+非典型抑郁症+恶劣心境障碍的遗传度为0.45，MD +非典型抑郁症+恶劣心境障碍+抑郁适应障碍的遗传度为0.46。大多数情况下，同一个人采访了双胞胎在pair.Conclusion：单极MD是中度遗传没有显着的共享家庭环境的影响。单相抑郁症合并在一起是中度遗传的，没有任何可检测的共同家庭环境影响。与单独MD相比，合并组的遗传力估计值倾向于更高。这项研究表明，在单相抑郁谱的障碍可能是相同的遗传倾向的不同表现。(C)2008 Elsevier B. V.保留所有权利。
Background: The purpose of this study was to estimate the contribution of genetic, common- and unique environmental factors in the aetiology of unipolar major depression (MD), and to investigate whether the unipolar depressive disorders: MD, atypical depression/depression NOS, dysthymia and depressive adjustment disorder can be viewed as various expressions of an underlying genetic commonality.Methods: A sample consisting of same-sexed mono- and dizygotic twins was drawn from in- and outpatient hospital registers (N = 303). DSM-III-R criteria were assessed by personal interviews. One hundred and forty-three of the probands fulfilled the criteria for one or another unipolar depressive disorder. Cross-tabulations were used to compare concordance rates for MD and different combinations of MD and other unipolar depressive disorders. Correlations in liability and estimations of the heritability (h(2)) with biometrical model fitting were performed.Results: Concordance rates were higher among MZ- than among DZ pairs for both MD and all the different combinations of MD and other unipolar depressive disorders. Cross-concordance between MD and other unipolar disorders was observed. In all instances, except for the situation when MD was considered alone, the correlations in liability among MZ pairs were more than twice the correlations in liability among DZ pairs. The heritability of MD was 0.42, of MD + atypical depression 0.51, of MD + atypical depression + dysthymia 0.45 and of MD + atypical depression + dysthymia + depressive adjustment disorder 0.46.Limitation: Probands were not sampled from the general population. Most often the same person interviewed both twins in a pair.Conclusion: Unipolar MD is moderately heritable without significant shared family environmental effects. Unipolar depressive disorders taken together are moderately heritable without any detectable shared family environmental effects. The tendency is towards higher heritability estimates for the combined groups compared to MD alone. The study suggests that the disorders in the unipolar depressive spectrum may be different manifestations of the same genetic liability. (C) 2008 Elsevier B.V. All rights reserved.