The Risk of a Second Hip Fracture in Patients after Their First Hip Fracture
The Risk of a Second Hip Fracture in Patients after Their First Hip Fracture
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DOI：
10.1007/s00223-011-9545-6
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发表时间：
2012-01-01
影响因子：
4.2
通讯作者：
Watanabe, Yoshinobu
中科院分区：
文献类型：
--
作者：
Hagino, Hiroshi;Sawaguchi, Takeshi;Watanabe, Yoshinobu
我们调查了初次髋部骨折后再次骨折的发生率和骨质疏松药物治疗处方的比率。我们调查了在2006年1月1日至2007年12月31日期间在日本五个地理区域的25家医院接受治疗的65岁及以上女性患者的首次髋部骨折。从病历中收集第一次髋部骨折后1年的数据，并向所有患者邮寄调查问卷。总共有2663名患者入选，335名患者根据排除标准被排除在外。对2328名患者进行了分析。在1年的随访期内，153名患者发生了160处骨折，77名患者发生了77处髋部骨折。在遭受第一次髋部骨折的患者中，所有额外骨折的发生率为70(每1000人年)，第二次髋部骨折的发生率为34。与普通人群相比，65岁的女性初次髋部骨折的几率是普通人群的四倍。436名患者(18.7%)接受了抗骨质疏松药物治疗，而1240名患者(53.3%)在1年内没有接受任何治疗。与普通人群相比，遭受过一次髋部骨折的患者发生第二次髋部骨折的风险更高，而且这些女性中的大多数都没有接受骨质疏松症的药物治疗。
We investigated the incidence of additional fractures and the rate of prescription of osteoporotic pharmacotherapy after an initial hip fracture. We surveyed female patients aged 65 and over who sustained their first hip fracture between January 1, 2006, and December 31, 2007, treated at 25 hospitals in five geographic areas in Japan. Data for 1 year after the first hip fracture were collected from medical records, and questionnaires were mailed to all patients. In total, 2,663 patients were enrolled, and 335 patients were excluded based on exclusion criteria. The analysis was performed on 2,328 patients. During the 1-year follow-up period 160 fractures occurred in 153 patients and 77 subsequent hip fractures occurred in 77 patients. The incidence of all additional fractures among patients who sustained their first hip fracture was 70 (per 1,000 person-year) and that for second hip fracture was 34. In comparison to the general population, women a parts per thousand yen65 years of age who sustained an initial hip fracture were four times as likely to sustain an additional hip fracture. Antiosteoporosis pharmacotherapy was prescribed for 436 patients (18.7%), while 1,240 patients (53.3%) did not receive any treatment during the 1-year period. Patients who have sustained one hip fracture have a higher risk of a second hip fracture compared to the general population, and most of these women receive no pharmaceutical treatment for osteoporosis.