Nervous system degeneration produced by the industrial solvent methyl n-butyl ketone.
Nervous system degeneration produced by the industrial solvent methyl n-butyl ketone.
复制标题
工业溶剂甲基正丁基酮产生的神经系统变性。
DOI：
10.1001/archneur.1975.00490460035002
复制
发表时间：
1975
影响因子：
--
通讯作者：
C. J. Terhaar
中科院分区：
文献类型：
--
作者：
P. Spencer;H. Schaumburg;R. L. Raleigh;C. J. Terhaar
由于1973年在一家纺织品印刷厂雇用的工人中发生了许多周围神经病病例，因此使用印刷油墨溶剂甲基正丁基酮（MBK）和甲基异丁基酮（MIBK）进行了慢性吸入实验。在间歇性呼吸暴露于百万分之1，300（ppm）MBK四个月后，所有六只受试大鼠的后肢都出现了严重的对称性无力。形态学研究表明，大量的局灶性轴突扩大含有异常大量的神经丝和周围和中枢神经纤维的轴突变性。6只大鼠同样暴露于1，500 ppm MIBK 5个月，表现出最小的远端轴突变化，但神经系统保持完整。本研究的主要结论是MBK是大鼠的神经毒素。
Because of a number of cases of peripheral neuropathy that occurred in factory workers employed in a fabric-printing plant in 1973, chronic inhalation experiments have been conducted using the printing-ink solvents methyl n-butyl ketone (MBK) and methyl iso-butyl ketone (MIBK). After four months of intermittent respiratory exposure to 1,300 parts per million (ppm) MBK, all six rats tested developed severe symmetric weakness in the hindlimbs. Morphological studies showed massive focal axonal enlargements containing abnormally large numbers of neurofilaments and dying-back axonal degeneration in peripheral and central nerve fibers. Six rats similarly exposed for five months to 1,500 ppm of MIBK showed minimal distal axonal change, but remained neurologically intact. The principal conclusion of this study is that MBK is a neurotoxin in rats.