ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy.
ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy.
复制标题
ABO 血型与肝细胞癌肝切除术后的生存相关
DOI：
10.1038/s41598-017-04046-4
复制
发表时间：
2017-06-30
影响因子：
4.6
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Wu T;Ma XA;Wang GQ;Li Q;Li MJ;Guo JY;Liang X;Ruan ZP;Tian T;Nan KJ;Liu LN;Guo H
ABO血型与几种恶性肿瘤的预后有关。然而，ABO血型在肝细胞癌（HCC）中的作用仍然难以捉摸。在此，我们通过考克斯回归分析评估了ABO血型在691例肝切除术后HCC患者中的预后作用。生成预后列线图以预测3年和5年总生存率（OS）。共有262名HCC患者（37.9%）为O型血，199名（28.8%）为A型血，165名（23.9%）为B型血，65名（9.4%）为AB型血。O型血患者的中位OS为55个月，A型血患者为39个月，B型血患者为34个月，AB型血患者为34个月（P= 0.001，对数秩检验）。O型和A型患者的OS存在显著差异[风险比（HR）= 1.416; 95% CI，1.101-1.820;P= 0.007]，B型患者的OS存在显著差异[风险比（HR）= 1.416; 95% CI，1.101-1.820;P= 0.007]，（HR = 1.736; 95% CI，1.333-2.262;P< 0.001），AB血型（HR = 1.739; 95% CI，1.210-2.499;P= 0.003）和非O血型（HR = 1.485; 95% CI，1.204-1.830;P< 0.001）。我们构建的列线图（c-index = 0.687）预测预后比单独的TNM分期（c-index = 0.601）更准确。总之，非O血型是肝切除术后肝癌预后不良的指标。我们的研究结果证明了在更大的队列中进一步的外部验证。
ABO blood types are associated with the prognosis of several malignancies. However, the role of the ABO blood type in hepatocellular carcinoma (HCC) remains elusive. Here, we evaluated the prognostic role of the ABO blood group in 691 HCC patients after hepatectomy by Cox regression analysis. A prognostic nomogram was generated to predict the 3 and 5-year overall survival (OS). A total of 262 HCC patients (37.9%) had blood group O, 199 (28.8%) had blood group A, 165 (23.9%) had blood group B, and 65 (9.4%) had blood group AB. The median OS was 55 months in patients with blood group O, 39 months for blood group A, 34 months for blood group B, and 34 months for blood group AB patients (P= 0.001, log-rank test). There were significant differences in OS between patients with blood groups O and A [hazard ratio (HR) = 1.416; 95% CI, 1.101–1.820;P= 0.007], blood group B (HR = 1.736; 95% CI, 1.333–2.262;P< 0.001), blood group AB (HR = 1.739; 95% CI, 1.210–2.499;P= 0.003) and non-O blood groups (HR = 1.485; 95% CI, 1.204–1.830;P< 0.001). Our constructed nomogram (c-index = 0.687) predicted the prognosis more accurately than the TNM stage alone(c-index = 0.601). In conclusion, non-O blood groups are poor prognostic indicators for HCC following hepatectomy. Our findings justify further external validation in larger cohorts.