R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus
R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus
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DOI：
10.1128/jvi.73.9.7817-7822.1999
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发表时间：
1999-09-01
影响因子：
5.4
通讯作者：
McCune, JM
中科院分区：
文献类型：
--
作者：
Berkowitz, RD;van't Wout, AB;McCune, JM
一些仅感染 1 型人类免疫缺陷病毒 R5 株的个体发展为艾滋病的速度与携带 X4 株的个体一样快。我们确定，在 SCID-hu Thy/Liv 小鼠中，三种 R5 病毒的致病性远低于 X4 病毒，这表明 R5 病毒介导的快速疾病进展与宿主因素有关，而不是与病毒因素有关。
Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors.