Functional neuroanatomy of auditory scene analysis in Alzheimer's disease
Functional neuroanatomy of auditory scene analysis in Alzheimer's disease
复制标题
DOI：
10.1016/j.nicl.2015.02.019
复制
发表时间：
2015-01-01
影响因子：
4.2
通讯作者：
Warren, Jason D.
中科院分区：
文献类型：
--
作者：
Golden, Hannah L.;Agustus, Jennifer L.;Warren, Jason D.
听觉场景分析是一个要求很高的计算过程，它是由健康的大脑自动有效地执行的，但容易受到阿尔茨海默病神经退行性病理的影响。在这里，我们评估了阿尔茨海默病听觉场景分析的功能神经解剖学，使用众所周知的“鸡尾酒会效应”作为模型范式，即听觉对象（例如，听到一个人说的名字）的存储模板用于分离听觉“前景”和“背景”。典型遗忘性阿尔茨海默病患者（n=13）和年龄匹配的健康个体（n=17）使用稀疏获取协议进行功能性3T-MRI，被动聆听听觉刺激条件，包括参与者自己的名字与多说话者的咿呀学语交织或叠加，以及这些条件的频谱旋转（无法识别）类似物。在AD组和健康对照组中，名字识别（包含参与者自己的名字与光谱旋转的类似物对比的条件）产生了涉及上颞叶皮层的广泛的双侧激活，两组之间没有显著差异。听觉对象分离（与交织的名字音和重叠的名字音对比）在两组中都产生了右侧后颞上皮层的激活，同样没有组间差异。然而，鸡尾酒会效应（自己的名字识别与听觉对象分离加工的相互作用）使AD组的右边缘上回的激活比健康对照组显著增强。研究结果描述了阿尔茨海默病听觉场景分析的功能神经解剖学特征的改变，这可能构成这种神经退行性病理的一种新的计算特征。(C) 2015年作者。Elsevier Inc.出版。
Auditory scene analysis is a demanding computational process that is performed automatically and efficiently by the healthy brain but vulnerable to the neurodegenerative pathology of Alzheimer's disease. Here we assessed the functional neuroanatomy of auditory scene analysis in Alzheimer's disease using the well-known 'cocktail party effect' as a model paradigm whereby stored templates for auditory objects (e.g., hearing one's spoken name) are used to segregate auditory 'foreground' and 'background'. Patients with typical amnestic Alzheimer's disease (n=13) and age-matched healthy individuals (n=17) underwent functional 3T-MRI using a sparse acquisition protocol with passive listening to auditory stimulus conditions comprising the participant's own name interleaved with or superimposed on multi-talker babble, and spectrally rotated (unrecognisable) analogues of these conditions. Name identification (conditions containing the participant's own name contrasted with spectrally rotated analogues) produced extensive bilateral activation involving superior temporal cortex in both the AD and healthy control groups, with no significant differences between groups. Auditory object segregation (conditions with interleaved name sounds contrasted with superimposed name sounds) produced activation of right posterior superior temporal cortex in both groups, again with no differences between groups. However, the cocktail party effect (interaction of own name identification with auditory object segregation processing) produced activation of right supramarginal gyrus in the AD group that was significantly enhanced compared with the healthy control group. The findings delineate an altered functional neuroanatomical profile of auditory scene analysis in Alzheimer's disease that may constitute a novel computational signature of this neurodegenerative pathology. (C) 2015 The Authors. Published by Elsevier Inc.