Meta-analysis of Oxygenation Saturation Targeting Trials Do Infant Subgroups Matter?
Meta-analysis of Oxygenation Saturation Targeting Trials Do Infant Subgroups Matter?
复制标题
DOI：
10.1016/j.clp.2019.05.003
复制
发表时间：
2019-09-01
影响因子：
2.1
通讯作者：
Askie, Lisa Maree
中科院分区：
文献类型：
--
作者：
Askie, Lisa Maree
对来自大约5000名婴儿的参与者数据进行了Meta分析，以指导极早产儿的血氧饱和度政策。新生儿氧合前瞻性荟萃分析显示，与较低范围相比，较高的氧饱和度范围导致死亡和坏死性小肠结肠炎减少，主要残疾无差异，但增加了经后36周时治疗的早产儿视网膜病变（ROP）和补充氧气的使用。91%至95%的范围可以推荐用于所有极早产儿，但应伴随着严格的监测，以预防和早期治疗ROP。
Participant data from approximately 5000 infants have been meta analyzed to guide oxygen saturation policy for extremely preterm infants. The Neonatal Oxygenation Prospective Meta-analysis showed that targeting a higher oxygen saturation range compared with a lower range resulted in decreased death and necrotizing enterocolitis and no difference in major disability but increased treated retinopathy of prematurity (ROP) and supplemental oxygen use at 36 weeks' postmenstrual age. The 91 % to 95% range can be recommended for all extremely preterm infants from birth but should be accompanied by stringent surveillance for the prevention and early treatment of ROP.