A dual role of p21 in stem cell aging
A dual role of p21 in stem cell aging
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DOI：
10.1196/annals.1395.036
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Rudolph, K. Lenhard
中科院分区：
文献类型：
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作者：
Ju, Zhenyu;Choudhury, Aaheli Roy;Rudolph, K. Lenhard
随着年龄的增长，成人干细胞功能会下降，这可能是器官动态平衡和再生能力下降的原因之一。衰老研究的一个新兴领域是分析限制成体干细胞功能的分子通路，以响应衰老过程中大分子损伤的积累。目前的数据表明，p21细胞周期抑制物在干细胞老化中具有双重作用：一方面，p21通过阻止急性损伤的干细胞的不适当循环来保护成年干细胞免受急性遗传毒性应激的影响。另一方面，p21的激活损害了衰老的端粒功能障碍小鼠的干细胞功能和存活，这表明p21检查点功能在慢性和持续性损伤的背景下是不利的，这种损伤在衰老过程中积累。这篇文章主要关注p21在衰老干细胞中的双重作用。
A decline in adult stem cell function occurs during aging, likely contributing to the decline in organ homeostasis and regeneration with age. An emerging field in aging research is to analyze molecular pathways limiting adult stem cell function in response to macromolecular damage accumulation during aging. Current data suggest that the p21 cell cycle inhibitor has a dual role in stem cell aging: On one hand, p21 protects adult stem cells from acute genotoxic stress by preventing inappropriate cycling of acutely damaged stem cells. On the other hand, p21 activation impairs stem cell function and survival of aging telomere dysfunctional mice indicating that p21 checkpoint function is disadvantageous in the context of chronic and persistent damage, which accumulates during aging. This article focuses on these dual roles of p21 in aging stem cells.