Collateral Vessels in Branch Retinal Vein Occlusion Anatomic and Functional Analyses by OCT Angiography
Collateral Vessels in Branch Retinal Vein Occlusion Anatomic and Functional Analyses by OCT Angiography
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DOI：
10.1016/j.oret.2019.04.015
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发表时间：
2019-09-01
影响因子：
4.5
通讯作者：
Kamei, Motohiro
中科院分区：
文献类型：
--
作者：
Tsuboi, Kotaro;Sasajima, Hirofumi;Kamei, Motohiro
目的：目的：应用OCT血管造影（OCTA）分析视网膜分支静脉阻塞（BRVO）相关侧支血管（CV）的解剖学和功能。设计：回顾性研究。参与者：29例连续BRVO患者。方法：应用光谱域OCTA研究BRVO发病12个月后CV的分布。从中央凹上的9个位置采集正面3 x 3 mm OCTA图像，并用于创建8.1 x 8.1 mm正方形的蒙太奇图像。在3个不同的区域中识别CV：径向乳头周围毛细血管（RPC）、浅毛细血管丛（SCP）和深毛细血管丛（DCP）层。在4个区域评估CV的数量：1区，以中心凹为中心的直径为3 mm的圆内的区域; 2区，直径为3 mm的圆与其直径为6 mm的圆之间的区域; 3区，直径为6 mm的圆以外的区域;以及颞缝。每层中CV数量和血管密度（VD）、12个月时持续性黄斑水肿（ME）以及抗血管内皮生长因子（VEGF）药物注射次数之间的关系。SCP中1区CV数与VD呈负相关（P = 0.0079），DCP中3区CV数与VD呈负相关（P = 0.0017），DCP中颞中缝CV数与VD呈负相关（P = 0.036）。RPC中的CV数和CV总数也与DCP中的VD呈负相关（分别为P = 0.0034和P = 0.0113）。在持续性ME的患者中，CV在1区的数量显着（P = 0.0156）大于非持续性ME的患者，并呈正相关（P = 0.025）与抗VEGF injections.Conclusions的数量：CV在BRVO形式作为毛细血管脱落的结果，被认为是代表视网膜毛细血管重塑。中央凹周围的CV可能是持续性ME的良好指标。（C）2019年美国眼科学会
Purpose: To analyze collateral vessels (CVs) associated with branch retinal vein occlusion (BRVO) anatomically and functionally using OCT angiography (OCTA).Design: Retrospective review.Participants: Twenty-nine consecutive patients with BRVO.Methods: The distribution of the CVs 12 months after the onset of BRVO was studied using spectral-domain OCTA. En face 3 x 3-mm OCTA images were acquired from 9 locations centered on the fovea and used to create a montage image of an 8.1 x 8.1-mm square. The CVs were identified in 3 separate areas: the radial peripapillary capillary (RPC), superficial capillary plexus (SCP), and deep capillary plexus (DCP) layers. The numbers of CVs were evaluated in 4 regions: zone 1, the area within a 3-mm diameter circle centered on the fovea; zone 2, the area between the 3-mm diameter circle and its outer 6-mm diameter circle; zone 3, the area beyond the 6-mm diameter circle; and the temporal raphe.Main Outcome Measures: The relationship between the number of CVs and vessel density (VD) in each layer, persistent macular edema (ME) at 12 months, and the number of injections of anti-vascular endothelial growth factor (VEGF) agents.Results: The number of CVs in zone 1 was correlated negatively (P = 0.0079) with the VD in the SCP, and the numbers of CVs in zone 3 and the temporal raphe were correlated negatively (P = 0.0017 and P = 0.036, respectively) with the VD in the DCP. The number of CVs in the RPC and total number of CVs were also correlated negatively (P = 0.0034 and P = 0.0113, respectively) with the VD in the DCP. In patients with persistent ME, the number of CVs in zone 1 was significantly (P = 0.0156) greater than in patients with nonpersistent ME and correlated positively (P = 0.025) with the number of anti-VEGF injections.Conclusions: The CVs in BRVO form as result of capillary dropout and are considered to represent remodeling of the retinal capillaries. The CVs around the fovea may be good indicators of persistent ME. (C) 2019 by the American Academy of Ophthalmology