COMPUTERIZED ANALYSIS OF EEG BACKGROUND ACTIVITY IN EPILEPTIC PATIENTS
COMPUTERIZED ANALYSIS OF EEG BACKGROUND ACTIVITY IN EPILEPTIC PATIENTS
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DOI：
10.1111/j.1528-1157.1991.tb05544.x
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发表时间：
1991-11-01
期刊：
影响因子：
5.6
通讯作者：
HAGIMOTO, H
中科院分区：
文献类型：
--
作者：
MIYAUCHI, T;ENDO, K;HAGIMOTO, H
采用脑电图图和t-统计显著性概率映射（t-SPM）对128例特发性癫痫患者和30例正常人的背景活动进行了研究。在癫痫患者中，脑电图背景活动显示，与对照组相比，δ、θ、α(1)和β(1)显著增加，α(2)活动减少。与对照组相比，未经治疗的癫痫患者δ、θ和α显著增加。在抗癫痫药物治疗的癫痫患者中，综合治疗组减缓最明显，其次是单一治疗组，然后是未治疗组。在癫痫发作类型中，部分性癫痫发作（PS）患者往往比全身性强直-阵挛发作（GTC）患者表现出更慢的速度。此外，PS在α(2)和β(1)活动上具有左右不对称性。在aed的比较中，卡马西平（CBZ）和苯巴比妥（PB）治疗组与未治疗组相比无显著差异。相比之下，接受丙戊酸钠（VPA）治疗的患者表现出慢速和快速活动的下降。每种AED与GTC和PS相关的脑电图变化是不同的。接受VPA治疗GTC的患者显示theta和beta(1)活动下降，而PS患者仅显示delta活动下降。
Background activity was studied in 128 idiopathic epilepsy patients and 30 normal controls using EEG topography and t-statistic significance probability mapping (t-SPM). In epileptic patients, EEG background activity showed a marked increase in delta, theta, alpha(1), and beta(1), and a decrease in alpha(2) activity as compared with controls. Untreated epileptic patients had a significant increase in delta, theta, and alpha, as compared with controls. For epileptic patients treated with antiepileptic drugs (AEDs), the most marked slowing was observed in the polytherapy group, followed by the monotherapy group and then the untreated group. Among seizure types, patients with partial seizures (PS) tended to exhibit more slowing than patients with only generalized tonic-clonic seizures (GTC). Moreover, PS had a right-left asymmetry in alpha(2) and beta(1) activities. In a comparison of AEDs, patients receiving carbamazepine (CBZ) and phenobarbital (PB) showed no significant difference as compared with the untreated group. In contrast, patients receiving valproate (VPA) showed a decrease in slow and fast activities. EEG changes associated with each AED were different in GTC and PS. Patients receiving VPA for GTC showed a decrease in theta and beta(1) activities, but those with PS showed a decrease only in delta activity.